We show that because of methodological improvements, the human modification map detects higher levels of land modification and is more accurate than the human footprint map across the gradient of modification globally. While we agree that protecting the world's least modified lands or wildlands is essential for conservation, we assert that extending conservation actions to better "manage the middle" are urgently needed to ensure healthy functioning ecosystems for people and nature. This article is a commentary on Kennedy et al., 25, 811-826; See also the Commentary on this article by Venter et al., 26, 330-332.
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http://dx.doi.org/10.1111/gcb.14900 | DOI Listing |
The mammalian kidney develops in three sequential stages referred to as the pronephros, mesonephros, and metanephros, each developing from the preceding form. All three phases of kidney development utilize epithelized tubules called nephrons, which function to take in filtrate from the blood or coelom and selectively reabsorb solutes the organism needs, leaving waste products to be excreted as urine. The pronephros are heavily studied in aquatic organisms such as zebrafish and Xenopus, as they develop quickly and are functional.
View Article and Find Full Text PDFinfects the urogenital tract of men and women and causes the sexually transmitted infection trichomoniasis. Since the publication of its draft genome in 2007, the genome has drawn attention for several reasons, including its unusually large size, massive expansion of gene families, and high repeat content. The fragmented nature of the draft assembly made it challenging to obtain accurate metrics of features, such as spliceosomal introns.
View Article and Find Full Text PDFCell Rep
January 2025
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Electronic address:
One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors. Despite significant advances in understanding the mechanisms of HIV-1 CA assembly and host factor interactions, HIV-2 CA assembly remains poorly understood. By templating the assembly of HIV-2 CA on functionalized liposomes, we report high-resolution structures of the HIV-2 CA lattice, including both CA hexamers and pentamers, alone and with peptides of host phenylalanine-glycine (FG)-motif proteins Nup153 and CPSF6.
View Article and Find Full Text PDFMolecules
January 2025
Institute for Preservation and Conservation of Chinese Ancient Books, Fudan University Library, Fudan University, 220 Handan Road, Shanghai 200433, China.
Paper-based cultural relics experience aging and deterioration during their long-term preservation, which poses a serious threat to their lifetime. The development of conservation materials with high compatibility and low intervention has been expected to extend the lifetime of paper artifacts. As a new type of biological macromolecule, nanocellulose has been extensively utilized in paper conservation, attributed to its excellent paper compatibility, high optical transparency, outstanding mechanical strength, and large specific surface area with abundant hydroxyl groups.
View Article and Find Full Text PDFLife (Basel)
January 2025
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Background: Many European countries' epidemiological data on burns were analyzed. This research aimed to analyze the key epidemiological characteristics of hospitalized burn patients in Serbia's major burn unit over 10 years, as well as to create the very first national epidemiological dataset with the basic requirements for future epidemiological studies.
Methods: A retrospective cross-sectional study was conducted, and demographic, clinical, and burn characteristics, as well as predictors of mortality, were analyzed.
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