Background: Hirschsprung's disease-associated enterocolitis (HE) is a life-threatening septic complication of Hirschsprung's disease (HD), leading to bacterial translocation (BT) and sepsis. Many factors, such as intestinal stasis, HD-related inherited immune disorders and abnormal mucosal secretion have been implicated in its pathogenesis.
Objectives: To investigate the effect of intestinal stasis as an independent factor in the pathogenesis of HE intestinal lesions and its systematic effects.
Material And Methods: The rectal ganglion cells of 46 Wistar rats were chemically ablated through local benzalkonium chloride (BAC) injection, in order to create a HD model (megacolon rats) that does not carry the possible genetic burden of HD. The animals were sacrificed either on the 20th or 25th day after ablation and were examined for histopathological changes on the wall of the small intestine, presence of bacterial translocation in body organs, body biometrics, and white blood cell count (WBC) and hemoglobin concentration. The results were compared to control animals.
Results: In the megacolon rats, severe damage on the small intestine as well as BT proportional to the extent of the intestinal damage and to the time elapsed after ablation was observed. Significant effects on the WBCs, hemoglobin concentration and biometric parameters were also observed.
Conclusions: In megacolon rats, intestinal stasis can lead by itself to a full-blown HE. The HE lesions that promote BT are present even in regions distant from the aganglionic bowel and are proportional to the time elapsed under the influence of intestinal stasis. Systematic effects such as growth retardation are also produced.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.17219/acem/109342 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnostic value of laboratory markers of enteric dysfunction in preterm infants.
Wiad Lek
December 2024
BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.
Objective: Aim: To study the peculiarities of food tolerance disorders in premature infants, taking into account the risk factors of gestational age and maternal labor, the peculiarities of the course of perinatal pathology, in order to determine pathogenetically sound clinical and laboratory criteria.
Patients And Methods: Materials and Methods: A comprehensive clinical and laboratory evaluation was performed on 67 preterm infants of gestational age 32 to 33/6 weeks with severe food tolerance disorders in perinatal pathology. The comparison group consisted of 31 newborns with gestational age of 34 to 37 weeks.
Rabbit Gastroenterology.
Vet Clin North Am Exot Anim Pract
December 2024
Zoo, Exotic and Wildlife Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; Small Animal Clinical Sciences Department, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
Gastrointestinal (GI) disorders are a common cause of emergency presentation in rabbits. Gastrointestinal stasis is a syndrome that is frequently caused by various primary conditions (including but not limited to affections of the GI tract itself). Over the last years, clinical features, diagnosis, management, and prognosis of GI disorders-such as GI obstructions, appendicitis, rabbit hemorrhagic virus disease, or liver lobe torsion-have been studied.
View Article and Find Full Text PDFUlcerated Jejunal Lipoma Causing Gastrointestinal Bleeding: A Case Report.
Cureus
November 2024
Endoscopy, Hospital Nove de Julho, São Paulo, BRA.
Lipomas of the small intestine are rare and generally asymptomatic. However, they can present with obstructive symptoms or gastrointestinal bleeding that is difficult to localize. A 63-year-old female patient was admitted to the emergency department with a complaint of melena for four days.
View Article and Find Full Text PDFBiliary microbiome and gallstones: A silent friendship.
World J Gastrointest Surg
November 2024
Department of General Surgery, All India Institute of Medical Sciences, Uttarakhand, Rishikesh 249203, India.
With increasing evidence, the biliary tract and the gallbladder mucosa are no longer considered sterile environments devoid of bacteria. Rather a profound biofilm of resident bacterial flora is associated with the mucosal surface. The bile too harbors a resident flora.
View Article and Find Full Text PDFImportance of scattered white spots detected in the duodenum and their relationship with zonulin.
Pak J Med Sci
December 2024
Selim Demirci, Department of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.
Objective: Scattered white spots (SWS) seen in the duodenum during esophagogastroduodenoscopy are rare lesions. The histopathologic examination of SWS lesions reveals normal duodenal mucosa (ND), chronic nonspecific duodenitis, and intestinal lymphangiectasia (IL). The intestinal epithelium, through its barrier function, is responsible for tightly controlling antigen traffic from the intestinal lumen to the submucosa.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!