AI Article Synopsis

  • Programmable nucleic acid nanoparticles (NANPs) enable targeted coordination of therapeutic nucleic acids (TNAs) and can stimulate specific immune responses, offering customization options in treatment methods.
  • Recent advancements in polymeric carriers enhance the protection of nucleic acids from degradation and improve their delivery inside cells.
  • A study comparing different NANP structures shows variations in their effectiveness for gene silencing, immunostimulation, and movement within the body, with fibrous NANPs being particularly promising for TNA delivery.

Article Abstract

Programmable nucleic acid nanoparticles (NANPs) provide controlled coordination of therapeutic nucleic acids (TNAs) and other biological functionalities. Beyond multivalence, recent reports demonstrate that NANP technology can also elicit a specific immune response, adding another layer of customizability to this innovative approach. While the delivery of nucleic acids remains a challenge, new carriers are introduced and tested continuously. Polymeric platforms have proven to be efficient in shielding nucleic acid cargos from nuclease degradation while promoting their delivery and intracellular release. Here, we venture beyond the delivery of conventional TNAs and combine the stable cationic poly-(lactide-co-glycolide)-graft-polyethylenimine with functionalized NANPs. Furthermore, we compare several representative NANPs to assess how their overall structures influence their delivery with the same carrier. An extensive study of various formulations both in vitro and in vivo reveals differences in their immunostimulatory activity, gene silencing efficiency, and biodistribution, with fibrous NANPs advancing for TNA delivery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942546PMC
http://dx.doi.org/10.1016/j.nano.2019.102094DOI Listing

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