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| http://dx.doi.org/10.1016/j.idc.2019.09.001 | DOI Listing |
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Impaired macroscopic CSF flow by sevoflurane in humans - both during and after anesthesia.
Anesthesiology
January 2025
Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Germany.
Background: According to the model of the glymphatic system, the directed flow of cerebrospinal fluid (CSF) is a driver of waste clearance from the brain. In sleep, glymphatic transport is enhanced, but it is unclear how it is affected by anesthesia. Animal research indicates partially opposing effects of distinct anesthetics but corresponding results in humans are lacking.
View Article and Find Full Text PDFCOVID-19 workplace countermeasures that occupational physicians could not change in Japan: a qualitative study.
BMC Public Health
January 2025
Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Fukuoka, Japan.
Background: During the COVID-19 pandemic, information and circumstances changed from moment to moment, including the accumulation of scientific knowledge, the emergence of variants, social tolerance, and government policy. Therefore, it was important to adapt workplace countermeasures punctually and flexibly based on scientific evidence and according to circumstances. However, there has been no assessment of changes in workplace countermeasures.
View Article and Find Full Text PDFNEW OCCURRENCES OF PHYTOTELMATA-INHABITING MOSQUITOES SPECIES IN NORTHWESTERN ARGENTINA.
J Am Mosq Control Assoc
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Unidad Ejecutora Lillo (CONICET-Fundación Miguel Lillo), San Miguel de Tucumán, Tucumán, Argentina.
The potential risk areas for emerging or reemerging diseases are determined by the presence, abundance, and distribution of mosquitoes. Here new records and geographical distribution extension of mosquito species in phytotelmata are updated for Argentina. We report for the first time Toxorhynchites bambusicola in Aechmea distichantha in Salta and Tucumán provinces, in the northwest region of Argentina.
View Article and Find Full Text PDFMetformin-encapsulating immunoliposomes conjugated with anti-TROP 2 antibody fragments for the active targeting of triple-negative breast cancer.
Nanoscale
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UPR 4301 CBM, CNRS, NMNS Department, University of Tours, 37200 Tours, France.
Trophoblast cell-surface antigen 2 (TROP 2) has re-emerged as a promising biomarker in triple-negative breast cancer (TNBC), with high overexpression in many TNBC cases. However, despite its potential and approval as an antibody-drug-conjugate for TNBC treatment, TROP 2-targeted delivery systems are currently underexplored. Therefore, this study was aimed at exploiting the potential of TROP 2 targeting by encapsulating metformin (Met), an antidiabetic drug associated with tumor growth inhibitory properties, inside liposomes decorated with TROP 2-targeting single-chain variable fragments (scFvs).
View Article and Find Full Text PDFCooling perspectives on the risk of pathogenic viruses from thawing permafrost.
mSystems
January 2025
U.S. Geological Survey, Geology, Minerals, Energy, and Geophysics Science Center, Moffett Field, Moffett Field, California, USA.
Climate change is inducing wide-scale permafrost thaw in the Arctic and subarctic, triggering concerns that long-dormant pathogens could reemerge from the thawing ground and initiate epidemics or pandemics. Viruses, as opposed to bacterial pathogens, garner particular interest because outbreaks cannot be controlled with antibiotics, though the effects can be mitigated by vaccines and newer antiviral drugs. To evaluate the potential hazards posed by viral pathogens emerging from thawing permafrost, we review information from a diverse range of disciplines.
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