Purpose: Dynamic electron arc radiotherapy (DEAR) is a novel dynamic technique that achieves highly conformal dose through simultaneous couch and gantry motion during delivery. The purpose of this study is to develop a framework integrating a Monte Carlo dose engine (VirtuaLinac) to a treatment planning system (TPS, Eclipse) for DEAR. A quality assurance (QA) procedure is also developed.
Methods And Materials: The interfaces include the following: computed tomography image export and conversion for VirtuaLinac; VirtuaLinac computation tasks management through application programming interface (API); and dose matrix processing and evaluation. The framework was validated with both static beam and DEAR plan with a 3 × 3 cm cutout for both 6 and 9 MeV electrons. Verification plans for DEAR were created on flat phantom and a hybrid dose calculation technique was developed which convolves precalculated small field kernel with the beam trajectory, and the resulting dose was compared with the full VirtuaLinac calculation and film measurement.
Results: Excellent agreement between VirtuaLinac and eMC was observed with three-dimensional γ pass rate of 98% at 1%/1 mm criteria for both 6 and 9 MeV electrons. Film measurement shows two-dimensional (2D) γ passing rate of 99.8 % (6 MeV) and 97.1% (9 MeV) at 2%/2 mm criteria. For DEAR plans the comparison of VirtuaLinac and measurement shows the 2D γ passing rates of 94% at 2%/2 mm for 6 MeV. The dose distributions from hybrid method in phantom are identical to the full VirtuaLinac simulations, but can be done instantly.
Conclusions: A framework has been developed for DEAR dose calculation using VirtuaLinac Monte Carlo dose engine. The VirtuaLinac calculated dose was validated against measurement. A feasible and practical DEAR QA method has been developed for dose measurement in phantom. The hybrid dose calculation technique is efficient and suitable for DEAR QA purpose.
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Sci Rep
January 2025
Faculty of Computer and Information, South Valley University, Qena, 83523, Egypt.
Ra, Th, and K levels in various foods frequently consumed by Egyptians were determined using a gamma-ray spectrometer based on the germanium detector (HPGe). Activity concentrations of Ra, Th, and K were in the range of < 0.10 to 0.
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January 2025
Radiation Safety and Quality Assurance division, National Cancer Center Hospital East, Chiba, 277-8577, Japan.
The impact of three-dimensional (3D) dose delivery accuracy of C-arm linacs on the planning target volume (PTV) margin was evaluated for non-coplanar intracranial stereotactic radiosurgery (SRS). A multi-institutional 3D starshot test using beams from seven directions was conducted at 22 clinics using Varian and Elekta linacs with X-ray CT-based polymer gel dosimeters. Variability in dose delivery accuracy was observed, with the distance between the imaging isocenter and each beam exceeding 1 mm at one institution for Varian and nine institutions for Elekta.
View Article and Find Full Text PDFFarm Hosp
January 2025
Servicio de Oncología Médica, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain.
Objective: Standard treatment of metastatic colorectal cancer includes oxaliplatin and 5-fluorouracil in continuous infusion. Although FOLFOX-6 is the reference combination, it is aggressive and has high toxicity. Variants such as the TTD regimen, which does not include folinic acid or 5-fluorouracil bolus, are used.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong 510275, China. Electronic address:
In the health risk assessment of pesticides, methods for external exposure assessment have been well developed. However, quantifying the contribution of various exposure pathways or routes to internal dose remains challenging. This study introduced the internal allocation factor (IAF) for 319 pesticides to investigate the impact of different exposure pathways and routes on chemical distribution within the human body.
View Article and Find Full Text PDFMed Phys
January 2025
Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, France.
Background: Breast cancer is the leading cause of female cancer mortality worldwide, accounting for 1 in 6 cancer deaths. Surgery, radiation, and systemic therapy are the three pillars of breast cancer treatment, with several strategies developed to combine them. The association of preoperative radiotherapy with immunotherapy may improve breast cancer tumor control by exploiting the tumor radio-induced immune priming.
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