The previous treatment options for neurotrophic keratopathy (NK) were limited. Frequently performed surgical procedures for severe NK include amnionic membrane transplantation and tarsorrhaphy. Corneal neurotization describes the transposition of a healthy donor nerve along the limbal circumference to re-establish corneal sensation and trophic function. The nerve transfer can be performed either by directly transpositioning the supraorbital nerve as described here or by using a sural nerve interponate.
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http://dx.doi.org/10.1007/s00347-019-00980-y | DOI Listing |
Pain Rep
February 2025
Pain Research Institute, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Introduction: Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the spinal cord, and 1 potential mechanism is spinal disinhibition. A biomarker of spinal disinhibition is impaired H-reflex rate-dependent depression (HRDD).
View Article and Find Full Text PDFCornea
December 2024
Department of Ophthalmology, Université de Montréal, Montreal, QC, Canada.
Purpose: To report a rare case of conjunctival neuroma after a successful corneal neurotization surgery.
Methods: The clinical file and histopathology slides of this patient who underwent surgical corneal neurotization for a neurotrophic keratopathy in the right eye were reviewed.
Results: A 70-year-old man with a history of severe herpetic (varicella zoster) neurotrophic keratopathy and keratouveitis in the right eye developed a corneal perforation, which required tectonic keratoplasty (May 2020).
Graefes Arch Clin Exp Ophthalmol
November 2024
Eye Clinic, ASST Santi Paolo E Carlo Hospital, University of Milan, Milan, Italy.
Proc Natl Acad Sci U S A
November 2024
Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina.
Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal epithelium and its abundant nerves are affected by ocular desiccation and inflammation. Although adaptive immunity and specifically CD4 T cells play a role in DED pathogenesis, the exact contribution of these cells to corneal epithelial and neural damage remains undetermined. To address this, we explored the progression of a surgical DED model in wild-type (WT) and T cell-deficient mice.
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