Myopia is an abnormal refractive status, explained by an excessive ocular lengthening mostly in posterior segments. Although growing evidence of anterior segments, specifically altered corneal geometries with biomechanical properties in myopes have been reported, the mechanism behind is poorly understood. We hereby prepared experimentally induced highly myopic chicks to investigate the molecular basis of corneal remodeling by applying a novel proteomic approach integrated with information dependent acquisition (IDA) and data independent quantification (SWATH-MS) analysis. As a result, differentially expressed protein biomarkers that might be involved in structural changes were screened based on the first of its kind unique chicken corneal proteome. All generated raw data from IDA and SWATH-MS are accessible at Peptide Atlas public repository (http://www.peptideatlas.org/PASS/PASS01410) for general release.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811982 | PMC |
| http://dx.doi.org/10.1016/j.dib.2019.104478 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Establishment and Evaluation of Rabbit Model for Corneal Ectasia by Photorefractive Keratectomy.
Exp Eye Res
January 2025
Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
The study aimed to compare the effects of different types of excimer laser keratectomy on rabbit corneas and to identify the optimal disease model for corneal ectasia. Additionally, investigating the structural and molecular alterations in the novel disease model helped explore the mechanisms underlying biomechanical cues in corneal ectasia. 2.
View Article and Find Full Text PDFChemically Hydrophobic and Structurally Antireflective Nanocoatings in Butterflies.
ACS Appl Bio Mater
January 2025
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, Geneva CH-1211, Switzerland.
Moth-eye nanostructures, known for their biological antireflective properties, are formed by a self-assembly mechanism. Understanding and replicating this mechanism on artificial surfaces open avenues for the engineering of bioinspired multifunctional nanomaterials. Analysis of corneal nanocoatings from butterflies of the genus reveals a variety of nanostructures with uniformly strong antiwetting properties accompanied by varying antireflective functionalities.
View Article and Find Full Text PDFHarnessing Tumor Cell-Derived Exosomes for Immune Rejection Management in Corneal Transplantation.
Adv Sci (Weinh)
January 2025
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.
Article Synopsis
- Transplantation is the key treatment for severe organ failures, but immune rejection often limits its success; this study explores a new approach using exosomes from melanoma cells to combat this issue.
- The research shows that these tumor-derived exosomes (B16-Exo) significantly reduce immune rejection in mouse corneal transplants, improving survival and reducing inflammation.
- Analysis reveals that B16-Exo influences important proteins, particularly JAK2 in the JAK-STAT pathway, which enhances the activity of immune-suppressing cells and reduces T cell activity, highlighting the potential of exosomes for improving transplant outcomes.
Corneal Refractive Surgery Considerations in Patients With History of Orthokeratology.
Eye Contact Lens
February 2025
University of Arizona College of Medicine - Phoenix (V.M.W.), Phoenix, AZ; Hoopes Vision Research Center (K.A.M., P.C.H., M.M.), Hoopes Vision, Draper, UT; John A. Moran Eye Center (M.M.), University of Utah School of Medicine, Salt Lake City, UT; and Utah Lions Eye Bank (M.M.), Murray, UT.
Objective: To review the current literature describing corneal changes observed with orthokeratology (ortho-k) use and to formulate preliminary recommendations for these patients seeking corneal refractive surgery.
Methods: The literature search was conducted through the PubMed, Scopus, and Ovid databases through June 4, 2024, for articles regarding corneal physiological, tomographic, and biomechanical changes secondary to ortho-k use.
Results: Forty-one articles were found describing several changes associated with ortho-k use, including higher corneal staining, central corneal epithelial thinning and midperipheral thickening, increased higher-order aberrations, decreased contrast sensitivity, reduced corneal hysteresis and corneal resistance factor, and alterations in the tear proteome.
Dual diagnosis of -related mitochondrial complex III deficiency and recessive -related cataracts.
Rare
August 2024
Brotman Baty Institute, Seattle, WA 98195, USA.
Article Synopsis
- - A rare genetic condition involving mitochondrial complex III deficiency and lactic acidosis, characterized by scalp alopecia, was identified in two unrelated cases and discussed further with a participant from the Undiagnosed Diseases Network (UDN).
- - The participant had two autosomal recessive disorders discovered through genome sequencing: mitochondrial complex III deficiency and cataracts, with specifics on previously documented pathogenic variants for each condition.
- - A combination of enzyme assays and cellular proteomics showed clear dysfunction in complex III and low levels of a crucial protein, validating the genetic mutations' pathogenic effects and broadening understanding of these rare disorders.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!