AI Article Synopsis
- MKP3 (MAP kinase phosphatase 3) is a member of a protein family important for development, cancer, and stress responses, but its role in insects, especially honeybees, has not been extensively studied.
- A study isolated the MKP3 gene from the honeybee species Apis cerana cerana, finding that it is highly conserved across species and particularly active during key developmental stages.
- The research revealed that when the AccMKP3 gene is silenced, antioxidant enzyme activities increase, indicating its crucial role in managing oxidative stress in response to environmental challenges.
Article Abstract
MAP kinase phosphatase 3 (MKP3), a member of the dual-specificity protein phosphatase (DUSP) superfamily, has been widely studied for its role in development, cancer, and environmental stress in many organisms. However, the functions of MKP3 in various insects have not been well studied, including honeybees. In this study, we isolated an MKP3 gene from Apis cerana cerana and explored the role of this gene in the resistance to oxidation. We found that AccMKP3 is highly conserved in different species and shares the closest evolutionary relationship with AmMKP3. We determined the expression patterns of AccMKP3 under various stresses. qRT-PCR results showed that AccMKP3 was highly expressed during the pupal stages and in adult muscles. We further found that AccMKP3 was induced in all the stress treatments. Moreover, we discovered that the enzymatic activities of peroxidase, superoxide dismutase, and catalase increased and that the expression levels of several antioxidant genes were affected after AccMKP3 was knocked down. Collectively, these results suggest that AccMKP3 may be associated with antioxidant processes involved in response to various environmental stresses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882995 | PMC |
| http://dx.doi.org/10.1007/s12192-019-01036-5 | DOI Listing |
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Article Synopsis
- * A study tested the oral toxicity of five common insecticides on four honey bee species, finding that the managed Asian honey bee (Apis cerana) showed the highest tolerance to these chemicals.
- * The wild species, particularly the giant (A. dorsata) and red dwarf honey bee (A. florea), were more sensitive to the pesticides, emphasizing the need for better pesticide risk assessments and regulations to protect various honey bee species.
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