Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2106/JBJS.RVW.18.00179 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations.
Clin Epigenetics
December 2024
Hereditary Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.
Background: Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affecting a mismatch repair gene (MLH1, MSH2, MSH6, PMS2). Occasionally, LS may be caused by constitutional MLH1 epimutation (CME) characterised by soma-wide methylation of one allele of the MLH1 promoter. Most of these are "primary" epimutations, arising de novo without any apparent underlying cis-genetic cause, and are reversible between generations.
View Article and Find Full Text PDFAdvancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids.
J Transl Med
December 2024
Department of Precision Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
Background: Patient-derived organoids (PDOs) represent a promising approach for replicating the characteristics of original tumors and facilitating drug testing for personalized treatments across diverse cancer types. However, clinical evidence regarding their application to esophageal cancer remains limited. This study aims to evaluate the efficacy of implementing PDOs in clinical practice to benefit patients with esophageal squamous cell carcinoma (ESCC).
View Article and Find Full Text PDFApplication of Cas9-Based Gene Editing to Engineering of Nonribosomal Peptide Synthetases.
Chembiochem
December 2024
National Institute of Advanced Industrial Science and Technology, Department of Life Science and Biotechnology Research Institute for Drug Discovery, 2-4-7 Aomi, Koto-ku, 135-0064, Tokyo, JAPAN.
Engineering of nonribosomal peptide synthetases (NRPSs) could transform the production of bioactive natural product derivatives. A number of recent reports have described the engineering of NRPSs without marked reductions in yield. Comparative analysis of evolutionarily related NRPSs can provide insights regarding permissive fusion sites for engineering where recombination may occur during evolutionary processes.
View Article and Find Full Text PDFRisk Factors and Treatment Strategies for Anastomotic Ulcers in Pediatric Intestinal Failure.
J Pediatr Surg
December 2024
Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
Purpose: Anastomotic ulcers (AUs) are a rare cause of morbidity in intestinal failure (IF). Prior studies of AUs have been small, descriptive reports. We evaluated a large cohort of IF patients to identify risk factors and describe treatment strategies for AUs.
View Article and Find Full Text PDFExecutive Function Strengths in Athletes: a Systematic Review and Meta-Analysis.
Brain Behav
January 2025
School of Physical Education, Shanghai University of Sport, Shanghai, China.
Objective: Whether athletes possess superior executive functions still needs further examination. Therefore, the aim of this study is to explore the executive function advantages of athletes and the differences in these advantages between open- and closed-skill sports through systematic review and meta-analysis.
Methods: Computer searches of CNKI, Web of Science, PubMed, ScienceDirect, and SPORTDiscus databases were conducted.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!