We report the first direct catalytic enantioselective allylation of acyclic α-ketiminoesters to afford α-allyl-α-aryl and α-allyl-α-trifluoromethyl amino esters in excellent isolated yield (91-99%) and with high optical purity (90-99+% ). The allylation proceeds on a gram scale with 5-10 mol % of indium(I) iodide and commercially available BOX-type ligands. The allylated products are easily converted to enantiomerically enriched α-substituted proline derivatives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.9b03574 | DOI Listing |
Publication Analysis
Top Keywords
allylation acyclic
8
amino esters
8
enantioselective catalytic
4
catalytic allylation
4
acyclic ketiminoesters
4
ketiminoesters synthesis
4
synthesis α-fully-substituted
4
α-fully-substituted amino
4
esters report
4
report direct
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!