AI Article Synopsis
- A 33-year-old woman with 4 years of unexplained infertility had an unexpectedly high follicle-stimulating hormone (FSH) level.
- The high FSH level appeared contradictory to other hormonal tests indicating polycystic ovarian syndrome (PCOS).
- Testing revealed that the elevated FSH was primarily due to an autoimmune complex (macro-FSH), suggesting that autoimmune factors should be considered in unexplained infertility and repeated IVF failures.
Article Abstract
We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778895 | PMC |
| http://dx.doi.org/10.1155/2019/3071649 | DOI Listing |
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