Scanned Proton Beam Performance and Calibration of the Shanghai Advanced Proton Therapy Facility.

The Shanghai Advanced Proton Therapy facility (SAPT) is a hospital-based facility that began construction in December of 2014 with commissioning of the first scanned proton beam line starting in October of 2017. Proton beams are extracted from a synchrotron accelerator with energies between 70 and 235 MeV. Beam delivery uses the modulated scanning and energy stacking techniques to produce a maximal scanning area of 40 × 30 cm at the iso-center. Prior to clinical use, the beam delivery system was characterized and calibrated following the guidelines of the IEC 62667 medical electronic equipment standard including the spot size in air, spot position, depth dose distributions, and lateral dose profiles, as well as the beam monitor calibrations following the IAEA TRS-398 recommendations with small differences. •The measured dosimetric results showed that the full width at half maximum (FWHM) for the beam spot size in air varied approximately from 6 mm to 13 mm. The dose fall-off (DDF) derived from the measured depth dose in water varied from 4.7 mm at 235 MeV to 0.7 mm at 70 MeV. The homogeneity of the scanned field was better than 2% for various energies as expected.•Furthermore, the beam reproducibility and proportionality delivery accuracy was also stable with the results better than 0.1% and 1% respectively. Finally, the dose monitor calibration factor, its reproducibility and stability were tested. Reproducibility tests exhibited a standard deviation (SD) result of less than 1% during the test period.•All the measured dosimetric parameters showed that the design specifications were well achieved and the results are suitable for being used as a part of the clinical commissioning and quality assurance program for treating patients.