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Managing vitamin D deficiency in inflammatory bowel disease. | LitMetric

Managing vitamin D deficiency in inflammatory bowel disease.

Frontline Gastroenterol

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Published: October 2019

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788352PMC
http://dx.doi.org/10.1136/flgastro-2018-101055DOI Listing

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