Background: Diabetic ketoacidosis (DKA) is a disorder of carbohydrate metabolism that causes frequent urination, emaciation, extreme tiredness and dehydration. There is little or no information available on DKA in male goat (buck). The present study was carried out to report a rare case of DKA in a buck.
Case Description: A 1.5 year old buck was presented with anorexia and cough. On physical examination of buck showed fever, dullness, poor body condition and pale conjunctival mucous membrane.
Findings/treatment And Outcome: The peripheral blood smear revealed the mixed infection of sp. and sp. The blood picture showed anaemia and leukocytosis. The animal was treated with buparvaquone 2.5 mg/kg( and long acting oxytetracycline (20 mg/kg). Post treatment evaluation was done 7 days after initial treatment. Animal showed mild improvement in feed intake, the body temperature becomes normal, but showed tachycardia with weak pulse. Subsequently, animal showed severe emaciation with frequent urination. Urinalysis revealed glycosuria, ketonuria and acidic urine (pH = 6.0). Serum biochemistry revealed hyperglycemia, hypoinsulinemia, increased level of fructosamine and triglycerides and confirmed spontaneous DKA. It was treated with biphasic isophane insulin (1.0 IU/kg) twice a day, regularly. The blood glucose level becomes normal after insulin therapy. Animal resumed adequate feed intake, improvement in haemoglobulin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), and weight gain was observed.
Conclusion: This case study gains significance, due to its successful recovery after insulin treatment, but it requires lifelong insulin therapy to manage insulin dependent diabetes mellitus (IDDM) in this goat.
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Front Clin Diabetes Healthc
January 2025
Department of Clinical Pharmacy, School of Pharmacy, Institute of Health Sciences, Wallaga University, Nekemte, Ethiopia.
Background: Diabetic ketoacidosis (DKA) is a serious and acute complication of diabetes mellitus. In Ethiopia, the mortality associated with acute diabetes complications ranges from 9.8% to 12%.
View Article and Find Full Text PDFIran J Basic Med Sci
January 2025
i+HeALTH Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC), 47012 Valladolid, Spain.
Objectives: While ketone bodies are not the main heart fuel, exercise may increase their uptake. Objectives: This study aimed to investigate the effect of 6-week endurance training and Pyruvate dehydrogenase kinase 4 )PDK4( inhibition on ketone bodies metabolism in the heart of diabetic rats with emphasis on the role of Peroxisome proliferator-activated receptor-gamma coactivator PGC-1alpha (PGC-1α).
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Front Oncol
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Department of Radiology, People's Hospital of Deyang City, Deyang, Sichuan, China.
Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms with intermediate biological potential and are characterized by spindle-shaped myofibroblastic cells and significant inflammatory infiltrates. This case report describes a 24-year-old male with diabetes who was admitted to the hospital for over three days of vomiting and abdominal pain and was initially diagnosed with diabetic ketoacidosis. Upon admission, an abdominal CT scan revealed a large cystic-solid mass in the abdominal cavity and multiple nodules in the mesentery, omentum, and peritoneum, suggesting a preliminary diagnosis of an intra-abdominal mesenchymal tumor with peritoneal metastasis.
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Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
The GLP-1 receptor-based agonists (GLP-1RAs) and SGLT2 inhibitors (SGLT2i) are major 21 century breakthroughs in diabetes and obesity medicine but there are important safety considerations regarding the perioperative and periprocedural management of individuals who are treated with these agents. GLP-1RAs have been linked to an increased risk of retained gastric contents and pulmonary aspiration while SGLT2i can be associated with diabetic ketoacidosis. This manuscript provides a narrative review of the available evidence for perioperative and periprocedural risks in people prescribed GLP-1RAs and SGLT2i.
View Article and Find Full Text PDFCurr Diabetes Rev
January 2025
Department of Pharmacology, Central University of Punjab, Ghudda, Bathinda, 151401, India.
The connection between COVID-19 and DM unveils a multifaceted interplay that significantly impacts disease severity and management strategies. Initial studies reveal that people with DM had higher severity rates of COVID-19 due to the infection by SARS-CoV-2. The virus solely induces hyperglycemia and, at the same time, profoundly influences the immune and inflammatory reactions, increasing the rate of severe complications and death among diabetes patients.
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