In vitro antibacterial and cytogenotoxicological properties of the aqueous extract of (DC) leaf.

Background: Microbial infection of the genital tract or semen is one of the leading causes of male infertility. Consequently, there is a need to seek alternative products from natural sources.

Objectives: The antibacterial, phytochemical and cytogenotoxicological assessments of the aqueous extract of leaf were evaluated.

Methods: The antibacterial potential of the extract was done via agar-well diffusion and microdilution techniques. The phytochemical analysis was done via standard protocols.The cytogenotoxicity of the extract were analyzed using the assay.

Results: All test organisms were found to be sensitive to the extract except where no measurable zone of inhibition could be ascertained at all concentrations assessed.The highest mean inhibition diameter of 21.33±1.20mm against was recorded and a concentration-dependent susceptibility noticed. The phytochemical results revealed the presence of saponins, flavonoid, glycoside, steroids, terpenoid and alkaloids. The root showed reduced mitotic indices following aconcentration-dependent increase in the extract.It can be said that the aqueous extract of had inhibitory activities against the tested pathogenic organisms with relative anti-tumour potential.

Conclusion: This study indicated, could be a potential source for antibacterial compounds for the possible treatment of male reproductive related infections.