AI Article Synopsis
- t-PA treatment is most effective for ischemic stroke patients if administered within 4.5 hours, as delayed treatment increases the risk of hemorrhagic transformation.
- Development of vasoprotective drugs could help improve outcomes and extend the treatment window for t-PA and endovascular thrombolysis.
- Research using rat models shows that delayed t-PA treatment raises VEGF levels, leading to blood-brain barrier degradation, but this effect can be inhibited with anti-VEGF therapies.
Article Abstract
Tissue plasminogen activator (t-PA) treatment is beneficial for patients with ischemic stroke within 4.5 h of stroke onset, because the risk of intracerebral hemorrhagic transformation (HT) increases with delayed t-PA treatment. The benefits of t-PA thrombolysis are heavily dependent on time to treatment. Development of vasoprotective drugs that attenuate HT after delayed t-PA treatment might improve the prognosis of stroke patients and extend the therapeutic time window of t-PA and endovascular thrombolysis. An angiogenic factor, vascular endothelial growth factor (VEGF), might be associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. By using a rat thromboembolic model, delayed t-PA treatment at 4 h after ischemia promoted expression of VEGF in BBB, matrix metalloproteinase-9 (MMP-9) activation, degradation of BBB components, and HT. We demonstrated that HT was inhibited by intravenous administration of an anti-VEGF neutralizing antibody/VEGF receptor antagonist. In addition, for clinical application, reverse translation studies, a path from bedside to bench, are necessary.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5692/clinicalneurol.cn-001346 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Hypertension is a risk factor for bleeding events and is included in the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/Alcohol concomitantly)score. However, the effects of blood pressure (BP) and changes in BP on bleeding events in patients undergoing percutaneous coronary intervention (PCI) remain poorly understood. This study is aimed to investigate the relationship between systolic BP (SBP) changes during hospitalisation and bleeding events in patients undergoing PCI.
View Article and Find Full Text PDFBuyang Huanwu Decoction prevents hemorrhagic transformation after delayed t-PA infusion via inhibiting NLRP3 inflammasome/pyroptosis associated with microglial PGC-1α.
J Ethnopharmacol
December 2024
Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, China; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, China; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:
Ethnopharmacological Relevance: Delayed tissue-type plasminogen activator (t-PA) thrombolysis, which has a restrictive therapeutic time window within 4.5 h following ischemic stroke (IS), increases the risk of hemorrhagic transformation (HT) and subsequent neurotoxicity. Studies have shown that the NLRP3 inflammasome activation reversely regulated by the PGC-1α leads to microglial polarization and pyroptosis to cause damage to nerve cells and the blood-brain barrier.
View Article and Find Full Text PDFTransforming Skin Cancer Diagnosis: A Deep Learning Approach with the Ham10000 Dataset.
Cancer Invest
November 2024
Department of Electronics and Communication Engineering, Mahendra College of Engineering, Minnampalli, Salem, India.
Article Synopsis
- Skin cancer is prevalent globally, particularly melanoma, which can spread aggressively, making early detection crucial for successful treatment.
- Researchers developed a new Deep Learning model called the Multi-Grained Enhanced Deep Cascaded Forest (Mg-EDCF) that classifies skin lesions into seven categories, improving diagnostic accuracy.
- When tested against previous models using the HAM10000 dataset, the Mg-EDCF achieved an impressive average accuracy of 98.19%, surpassing existing state-of-the-art algorithms.
Neuropsychological outcomes following endovascular clot retrieval and intravenous thrombolysis in ischemic stroke.
J Int Neuropsychol Soc
October 2024
Department of Psychology, Counselling & Therapy, School of Psychology & Public Health, La Trobe University, Melbourne, Australia.
Objectives: Cognitive impairment, anxiety, depression, fatigue, and dependence in instrumental activities of daily living (ADL) are common after stroke; however, little is known about how these outcomes may differ following treatment with endovascular clot retrieval (ECR), intravenous tissue plasminogen activator (t-PA), or conservative management.
Methods: Patients were recruited after acute treatment and invited to participate in an outcome assessment 90-120 days post-stroke. The assessment included a cognitive test battery and several questionnaires.
The hemostatic activity and Mechanistic roles of glucosyloxybenzyl 2-isobutylmalate extract (BSCE) from (Thunb.) Rchb.f. in Inhibiting pulmonary hemorrhage.
Heliyon
September 2024
Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Article Synopsis
- Hemorrhagic events lead to numerous deaths globally, creating a demand for effective hemostatic drugs; BSCE, derived from the orchid plant, shows promise in treating bleeding mice but needs further investigation for non-traumatic bleeding.
- In a study with 40 rats, BSCE was administered to assess its impact on various health metrics, including red blood cell count and lung tissue pathology, compared to a control group and a positive treatment group.
- Results indicated BSCE improved body weight, red blood cell levels, and lung tissue condition while positively influencing coagulation parameters and revealing potential biological pathways for hemostatic action via network pharmacology and molecular docking analysis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!