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Comparative effectiveness, safety and persistence of ocrelizumab versus natalizumab in multiple sclerosis: A real-world, multi-center, propensity score-matched study.
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Department of Human Neurosciences, Sapienza University, Rome, Italy. Electronic address:
Ocrelizumab (OCR) and Natalizumab (NTZ) are highly effective treatments widely used in Multiple Sclerosis (MS). However, long-term, real-world comparative data on clinical effectiveness, safety and treatment persistence are limited. This retrospective analysis included relapsing and progressive MS patients initiating treatment at two Italian Universities ("La Sapienza" and "Federico II").
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Department of Psychiatry and Department of Epidemiology and Biostatistics, Western University, St Thomas, Canada.
Background: Generalised anxiety disorder (GAD) is a mental health condition characterised by excessive anxiety and worry about everyday events. GAD is a common disorder and generally affects women twice as often as men. Treatments include various psychological and pharmacological therapies.
View Article and Find Full Text PDFHippocampal DNA methylation promotes contextual fear memory persistence by facilitating systems consolidation and cortical engram stabilization.
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Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany; Department of Molecular and Cellular Cognition Research, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany. Electronic address:
Background: Long-term fear memory storage involves gradual reorganization of supporting brain regions over time, a process termed systems consolidation. Memories initially rely on the hippocampus but gradually shift dependence to the neocortex. Although hippocampal activity drives this transfer, the molecular basis of systems consolidation is largely unknown.
View Article and Find Full Text PDFAsphalt pavement emission behavior under solar radiation during in-service period.
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School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
The toxic fume emitted from asphalt pavement remains a health and environmental hazard towards public safety, especially the emission of volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs). Despite extensive studies focused on characterizing asphalt fumes generated during construction stages (i.e.
View Article and Find Full Text PDFThe influence of atmospheric temperature on long-term CPAP-usage in patients with obstructive sleep apnea.
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Groupe Adène, Montpellier, France; Department of Respiratory Diseases, Montpellier University Hospital, Arnaud de Villeneuve Hospital, Montpellier, France; PhyMedExp (INSERM U 1046, CNRS UMR9214), Montpellier University, Montpellier, France. Electronic address:
Background: Although seasonal variations in CPAP-usage are often attributed to changes in temperature, no real-world study has evaluated the influence of temperature on long-term CPAP-usage.
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