Fully automated preparation of Ga-PSMA-11 at curie level quantity using cyclotron-produced Ga for clinical applications.

Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available Ge/Ga generator. Ge/Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of Ga/Ge generators has not been able to meet the increasing demand of Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing Ga-PSMA-11, using cyclotron-produced Ga that is ready for routine clinical practice.