AI Article Synopsis
- The study aims to assess how muscle atrophy in the levator muscle of patients with unilateral congenital ptosis varies with the patient's age at the time of surgery.
- Histological analysis of the levator muscle from 29 patients revealed that younger patients (2-4 years) experienced mild atrophy, while older patients (4.1-11 years) exhibited severe atrophy characterized by significant muscle fiber changes.
- The findings suggest that not only does muscle degeneration occur after surgery, but severity increases with the patient's age, indicating that delaying surgical intervention could lead to worse muscle atrophy.
Article Abstract
Purpose: To evaluate the different degree of muscle atrophy in specimens of levator muscle of patients operated on for unilateral congenital ptosis, as related to the age of the patient.
Methods: Histological analysis of the specimen of the levator muscle of 29 patients who underwent a unilateral levator muscle resection under the care of one surgeon was performed. The study population was divided into two different groups according to the timing of surgery: group 1 included 15 children operated on at 2 to 4 years, and group 2 included 14 children operated on at 4.1 to 11 years.
Results: Levator muscle of 12 patients of group 1 showed mild degree of muscle atrophy, with striated muscle fibres separated by thin fibrous septa incorporating groups of cells with peripheral nuclei and non-hyalinized cytoplasm (Masson's trichrome stain). In eight cases of group 2, levator muscle showed instead severe atrophy, with discontinuous striated muscle fibres separated by thick fibrous septa including cells with centralization of nuclei, hyalinization of cytoplasm (Masson's trichrome stain) and fatty infiltration.
Conclusion: Myofibres found in specimens of levator muscle following levator resection for congenital ptosis show characteristics of a degenerative process. This study seems to demonstrate that atrophy in the levator muscle appears to be related to the age of the patient at surgery, as atrophy tends to be more evident in older children with congenital ptosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/aos.14284 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysing the support mechanisms of the vaginal ring pessary on supine and upright MRI.
Sci Rep
December 2024
Multi-Modality Medical Imaging (M3I), TechMed Centre, University of Twente, Technohal 2384,Drienerolaan 5, Enschede, 7522NB, The Netherlands.
Vaginal pessaries have been used for millennia to alleviate symptoms of pelvic organ prolapse (POP). Despite their long-standing use, the success rate of pessary treatment is approximately 60%, and the underlying mechanisms of support are not well understood. This study aims to investigate three previously proposed hypotheses regarding the support mechanisms of pessaries, utilizing supine and upright magnetic resonance imaging (MRI): (1) support by bony structures, (2) support by levator ani muscles (LAM), and (3) the uterus keeping the pessary in place by acting as a lever.
View Article and Find Full Text PDFRacial Differences in the Levator Ani Muscle and Levator Hiatus in Individuals of Reproductive Age.
Am J Obstet Gynecol
December 2024
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:
Background: Most studies on pelvic floor muscle morphology (dimensions, shape) and its relationship with patient characteristic risk factors of pelvic floor dysfunction (demographics, medical history) have largely pertained to White individuals with vaginas. There is a need to establish normative data on pelvic floor muscle anatomy and identify morphological differences in racially diverse cohorts that may play a role in racial differences in the prevalence and pathophysiology of pelvic floor dysfunction.
Objective: (s): This study aimed to compare levator ani muscle thickness and levator hiatal morphology and their association with patient characteristics, between asymptomatic Black and White women-identifying individuals with a vagina of reproductive age.
Anatomical etiology of bunny lines based on cadaveric dissection and ultrasonographic evaluation.
Clin Anat
December 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
Bunny lines are vertical and diagonal wrinkles attributed to contractions of the nasalis muscle. Common management involves botulinum toxin (BoNT) injections into wrinkles immediately below the nasal bridge. Here, we investigated the anatomical structures underneath bunny lines and their relationships with adjacent muscular structures.
View Article and Find Full Text PDFShortened Fornix Syndrome After Posterior-Approach Ptosis Repair.
Ophthalmic Plast Reconstr Surg
December 2024
Division of Oculofacial Plastic and Reconstructive Surgery, Shiley Eye Institute, UCSD, La Jolla, California, U.S.A.
Purpose: To describe and characterize shortened fornix syndrome (SFS), a rare complication following posterior-approach ptosis repair using conjunctival Müller muscle resection.
Methods: This retrospective case series evaluates 4 patients who developed SFS after conjunctival Müller muscle resection. Clinical characteristics, surgical histories, management, and outcomes are reviewed.
Ultrasonographic evaluation of diastasis recti abdominis and its association with pelvic floor dysfunction in postpartum women: a cross-sectional study of a two-year retrospective cohort.
Front Med (Lausanne)
December 2024
Department of Rehabilitation, Shanghai East Hospital, Tongji University, Shanghai, China.
Objective: This study aims to evaluate the ultrasonographic findings of Diastasis Recti Abdominis (DRA) in postpartum women, explore associated risk factors, and assess the relationship between DRA and pelvic floor dysfunction.
Methods: This retrospective cross-sectional study included 143 parturient women diagnosed with DRA at our institution from January 2022 to December 2023. The study aimed to assess the ultrasonographic characteristics and clinical implications of DRA in postpartum women.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!