AI Article Synopsis
- The study aims to assess how effective ultra-short echo time (UTE) MRI sequences are for imaging the distribution of nebulized contrast agents in lungs that are similar in size to humans.
- Researchers used a jet nebulizer to deliver gadolinium-based contrast agents into ventilated porcine lungs and acquired MR images using 3D UTE sequences, achieving high-resolution images in under 4 minutes.
- Results showed significant MR signal enhancement after nebulization, allowing visualization of aerosol deposition in lung structures, with a correlation found between MRI measurements and the amount of gadolinium used, indicating potential for future clinical applications without using ionizing radiation.
Article Abstract
Purpose: The objective of this study is to evaluate the suitability and performance of ultra-short echo time (UTE) sequences for imaging and quantifying the deposition of nebulized MRI contrast agents in human-sized lungs.
Methods: Nebulization of clinically used contrast agent or gadolinium-based nanoparticles were performed using a commercial jet nebulizer in isolated and ventilated porcine lungs connected to a 3D-printed human upper airways replica. MR images of isolated lungs were acquired on a 3T clinical MR scanner using 3D UTE sequences at different flip angles.
Results: 3D acquisitions with isotropic millimetric resolution were obtained in less than 4 min. Images exhibit homogeneous and large MR signal enhancement (above 200%) following nebulization of both types of aerosols. Deposition of aerosol down to the level of the bronchi of secondary lobules was visualized. T values and the concentration of nanoparticles obtained by MRI were found to correlate with the amount of nebulized gadolinium ions.
Conclusion: The distribution of aerosolized gadolinium-based contrast agent or nanoparticles can be visualized and quantified using UTE MRI in large animal ventilated lung model on a clinical MRI scanner. This protocol can be used for assessing and quantifying aerosol regional deposition with high spatial resolution (1 mm 3D isotropic) without ionizing radiation and could be applied in the future for diagnostic or therapeutic applications in patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mrm.28041 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fast and automated monitoring of gadolinium-based contrast agents in surface waters.
Water Res
December 2021
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany. Electronic address:
Gadolinium-based contrast agents (GBCAs) are frequently used for magnetic resonance imaging to improve image contrast. These inert complexes are excreted unmetabolized from the human body and pass through wastewater treatment plants almost unaffected, leading to a significant release of anthropogenic Gd into the environment. However, long-term ecotoxicological effects of GBCAs are mainly unknown and thus powerful methods of speciation analysis are required to monitor their distribution and fate in aquatic systems.
View Article and Find Full Text PDFNebulised Gadolinium-Based Nanoparticles for a Multimodal Approach: Quantitative and Qualitative Lung Distribution Using Magnetic Resonance and Scintigraphy Imaging in Isolated Ventilated Porcine Lungs.
Int J Nanomedicine
December 2020
INSERM U 1059 Sainbiose, Université Jean Monnet, Saint-Etienne, France.
Purpose: This study aims at determining lung distribution of gadolinium-based polysiloxane nanoparticles, AGuIX (small rigid platform - SRP), as a potential theranostic approach by the pulmonary route.
Methods: First, the aerodynamic size distribution and the aerosol output rate were thoroughly characterized. Then, a multimodal approach using magnetic resonance (MR) and gamma-camera (GC) imaging allows to assess the deposition of the aerosolised nanoparticles in the respiratory tract using isolated ventilated porcine lungs.
Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells.
J Nanobiotechnology
September 2020
INSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
Liquid deposit mimicking surface aerosolization in the airway is a promising strategy for targeting bronchopulmonary tumors with reduced doses of nanoparticle (NPs). In mimicking and studying such delivery approaches, the use of human in vitro 3D culture models can bridge the gap between 2D cell culture and small animal investigations. Here, we exposed airway epithelia to liquid-apical gadolinium-based AGuIX NPs in order to determine their safety profile.
View Article and Find Full Text PDFThree-dimensional quantitative MRI of aerosolized gadolinium-based nanoparticles and contrast agents in isolated ventilated porcine lungs.
Magn Reson Med
May 2020
Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, Saint-Etienne, France.
Article Synopsis
- The study aims to assess how effective ultra-short echo time (UTE) MRI sequences are for imaging the distribution of nebulized contrast agents in lungs that are similar in size to humans.
- Researchers used a jet nebulizer to deliver gadolinium-based contrast agents into ventilated porcine lungs and acquired MR images using 3D UTE sequences, achieving high-resolution images in under 4 minutes.
- Results showed significant MR signal enhancement after nebulization, allowing visualization of aerosol deposition in lung structures, with a correlation found between MRI measurements and the amount of gadolinium used, indicating potential for future clinical applications without using ionizing radiation.
Magnetic resonance imaging evaluation of the distribution of spray and irrigation devices within the sinonasal cavities.
Int Forum Allergy Rhinol
September 2019
Department of Surgery, The University of Auckland, Auckland, New Zealand.
Background: Optimizing intranasal distribution and retention of nasal sprays is essential in the management of patients with chronic rhinosinusitis (CRS), including those that have had functional endoscopic sinus surgery (FESS). Despite multiple existing distribution studies, there remains a need for a technique that allows regionalization of particle deposition within a patient's unique 3-dimensional (3D) geometry without exposing the patient to radiation.
Methods: Seven participants delivered normal saline containing a gadolinium-based contrast agent (GBCA) by either saline irrigation or nasal sprays on 1 side of the nasal cavity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!