Purpose: Ripple map (RM) is a novel method for displaying activation pattern on the surface of a cardiac chamber. The aim of this study was to determine the utility of the RM in interpreting the atrial propagation in atrial tachycardia (AT) in comparison with a conventional local activation (LAT) map.
Methods: Three-dimensional electroanatomical mapping and ablation of AT were performed using multielectrode catheters and the CARTO3 ConfiDENSE Module (Biosense Webster). LAT maps and RMs were retrospectively reviewed by two independent observers who were blinded to the ablation results.
Results: High-density maps (1683 ± 1362 points) of 45 ATs (274 ± 64 ms; macroreentry 28, focal 17) were obtained in 39 patients. Of the 45 ATs, 41 (91%) were terminated by catheter ablation. A retrospective review of the LAT map alone by two observers resulted in correct diagnosis in 27% (12 ATs), whereas additional reviews of the RMs improved the diagnostic accuracy to 80% (36 ATs, P < 0.001). The diagnostic accuracy using the RM was equally high for macroreentrant (79%) and focal ATs (82%, P = 1.000). Of the 33 LAT maps in disagreement with the observers, adjusting the window-of-interest (WOI) after reviewing the RMs achieved diagnostic agreement of 91% (30 ATs).
Conclusion: RMs allow us to have precise understanding of the atrial propagation on high-density CARTO maps for both focal and macroreentrant ATs, which is particularly useful for cases with difficult-to-interpret LAT maps.
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http://dx.doi.org/10.1007/s10840-019-00638-4 | DOI Listing |
Physiol Res
December 2024
Children's Heart Center, Second Faculty of Medicine, Charles University and Motol University Hospital, Praha, Czech Republic.
Although the heart atria have a lesser functional importance than the ventricles, atria play an important role in the pathophysiology of heart failure and supraventricular arrhythmias, particularly atrial fibrillation. In addition, knowledge of atrial morphology recently became more relevant as cardiac electrophysiology and interventional procedures in the atria gained an increasingly significant role in the clinical management of patients with heart disease. The atrial chambers are thin-walled, and several vessels enter at the level of the atria.
View Article and Find Full Text PDFHeart Rhythm
January 2025
Department of Molecular Biosciences, University of California, Davis, CA, USA; Department of Basic Sciences, California Northstate University, Elk Grove, CA. Electronic address:
Background: Friedreich's ataxia (FA) is a rare inherited neuromuscular disorder, where most patients die from lethal cardiomyopathy and arrhythmias. Mechanisms leading to arrhythmic events in FA patients are poorly understood.
Objective: This study aims to examine cardiac electrical signal propagation in mouse model of FA with severe cardiomyopathy and evaluate effects of omaveloxolone (OMAV), the first FDA-approved therapy.
JACC Clin Electrophysiol
November 2024
Department of Cardiology, Institute of Science Tokyo, Tokyo, Japan.
Background: Conventional endocardial mapping cannot fully elucidate Marshall bundle (MB)-related atrial tachycardia (AT).
Objectives: This study aimed to clarify the clinical and electrophysiological characteristics of MB-related AT definitively diagnosed using catheter insertion.
Methods: Forty-eight patients with AT who had previously undergone mitral isthmus ablation were enrolled in this study.
J Interv Card Electrophysiol
November 2024
Cortex Inc, Menlo Park, CA, USA.
Int J Mol Sci
November 2024
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
The pulmonary vein wall contains a myocardial layer whose ectopic automaticity is the major cause of atrial fibrillation. This review summarizes the results obtained in isolated pulmonary vein myocardium from small experimental animals, focusing on the studies with the guinea pig. The diversity in the action potential waveform reflects the difference in the repolarizing potassium channel currents involved.
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