Background: Ralstonia mannitolilytica is an emerging opportunistic pathogen that is associated with severe disease, including septic shock, meningitis, and renal transplant infections. Reports on this pathogen are limited, however, especially on the African continent.
Case Presentation: A 2-year-old Akan child was presented to a hospital in the northeastern part of Ghana with a 1-week history of fever and chills. We identified Ralstonia mannitolilytica in her blood culture using both conventional and 16S ribosomal deoxyribonucleic acid (rDNA) techniques. The patient's condition improved clinically upon treatment with cefuroxime.
Conclusion: Our report highlights the potential of Ralstonia mannitolilytica to cause sepsis and thus emphasizes the need for improved laboratory diagnosis and evidence for use of appropriate antibiotics in rural settings of Africa, where presumptive treatment using antimicrobial agents is rife.
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| http://dx.doi.org/10.1186/s13256-019-2235-0 | DOI Listing |
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Hidden in Plain Sight: Ralstonia mannitolilytica as a Rare Cause of Urinary Tract Infections.
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Children admitted to hospitals have been shown to frequently suffer from urinary tract infections (UTIs), with being the most common cause. is commonly found in plants, soil, and water sources. Since species are resistant to many antimicrobials, such as carbapenems, treating an infection with is challenging.
View Article and Find Full Text PDFRalstonia mannitolilytica infection in a tertiary care center: An outbreak report.
Am J Infect Control
September 2024
Paediatric Infectious Diseases Section, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Background: This paper describes an outbreak of Ralstonia mannitolilytica infection declared at our facility between January-2021 and January-2022.
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Article Synopsis
- Ralstonia mannitolilytica is a worldwide pathogen linked to various illnesses, especially in patients with chronic obstructive pulmonary disease (AECOPD), where it can cause bacteremia.* -
- The researchers employed techniques like the Vitek2™ system and 16S rRNA sequencing to identify the bacteria, and they sequenced its genome using advanced technology to analyze its genetic features.* -
- The study revealed a complete genome with two chromosomes containing numerous antibiotic resistance genes and virulence factors, enhancing the understanding of its role in AECOPD.*
Ralstonia mannitolilytica Infections: A Systematic Review of Case Reports Unveiling Clinical Patterns and Therapeutic Insights.
Curr Drug Res Rev
May 2024
Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Background: Ralstonia mannitolilytica is an emerging opportunistic pathogen that has been increasingly reported in clinical settings. Despite its low pathogenicity in immunocompetent individuals, it poses a significant threat to immunocompromised patients, particularly those with underlying medical conditions or invasive medical interventions.
Objectives: This study aimed to evaluate the clinical impact and management strategies based on the analysis of individual case reports on Ralstonia mannitolilytica .
Phenotypic and genetic characterization of a lipolytic Ralstonia mannitolilytica isolate from petroleum-contaminated soil in Iraq.
Mol Biol Rep
April 2024
Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq.
Article Synopsis
- Microbial lipases, especially from bacteria, are important for industrial applications and can help address environmental concerns related to hydrocarbons from refineries.
- In this study, 40 bacterial isolates from contaminated soils in Iraq were tested, identifying 12 that produced lipases, with Ralstonia mannitolilytica showing the highest activity.
- Genetic analysis confirmed the species and revealed significant genetic variations, positioning Ralstonia mannitolilytica as a valuable candidate for biotechnological use in breaking down hydrocarbons and industrial processes.
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