AI Article Synopsis
- - Lupus nephritis (LN) is a serious complication of lupus that leads to renal damage, but the exact mechanisms behind this damage are not fully understood.
- - The study focuses on how immune complexes, specifically heat-aggregated gamma globulin (HAGG), harm glomerular endothelial cells (GECs), which are crucial for kidney function.
- - Findings showed that HAGG negatively affected GEC functions by altering cell shape, enhancing apoptosis (cell death), reducing angiogenesis (blood vessel formation), and increasing nitric oxide production, shedding light on renal damage in LN.
Article Abstract
Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the present study, we used heat-aggregated gamma globulin (HAGG) to simulate immune complexes and investigated their effects on GEC functions. Our results revealed that HAGG impaired different aspect of the GEC functions. HAGG changed cell morphology, upregulated the expression of active caspase-3, inhibited angiogenesis, and increased NO production in GECs. These results provide new clues for the mechanisms of renal damage and the pathology of LN.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862593 | PMC |
| http://dx.doi.org/10.3390/ijms20215281 | DOI Listing |
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