Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865213 | PMC |
| http://dx.doi.org/10.3390/molecules24213812 | DOI Listing |
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