Introduction: Video capsule endoscopy (VCE) is a useful tool to differentiate small intestinal bleeding, inflammatory bowel disease, and other small bowel disease. The most common adverse effect of VCE is capsule retention; the incidence varies greatly depending on the underlying disease, which is known to increase from 1.5% in healthy individuals to 21% in patients with small bowel Crohn disease. We report this case on a patient who had asymptomatic capsule retention for 12 months and experienced natural elimination with medication.
Patient Concerns: A 21-year-old woman presented to the hospital with chronic abdominal pain and persistent diarrhea for 2 years.
Diagnoses: The patient was diagnosed with small bowel Crohn disease using VCE, and radiography revealed capsule retention.
Intervention: Symptoms of obstruction were not distinctive, it was decided to increase the dosages of azathioprine and infliximab to 50 and 500 mg (10 mg/kg), at 5 months after VCE. And at month 11 of capsule retention, she was admitted and started on a regimen of hydrocortisol 300 mg for 4 days and hydrocortisol injection 200 mg for 10 days.
Outcomes: At month 12, abdominal radiography in the clinic confirmed that the capsule had been naturally retrieved.
Lessons: Capsule retention could be initially treated conservatively with medication and if the treatment fails, it is recommended to remove the capsule surgically. But in the case of the clinical condition of the patient is favorable without symptoms of bowel obstruction, the medication should be continued and the patient followed up.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824652 | PMC |
http://dx.doi.org/10.1097/MD.0000000000017580 | DOI Listing |
Nat Commun
January 2025
State Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, 300071, P.R. China.
Two or more catalysts conducting multistep reactions in the same reactor, concurrent tandem catalysis, could enable (bio)pharmaceutical and fine chemical manufacturing to become much more sustainable. Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent organic framework capsule, COFcap-2, functions like an artificial cell in that, whereas the catalysts are trapped within 300-400 nm cavities, substrates/products can ingress/egress through ca. 2 nm windows.
View Article and Find Full Text PDFFood Res Int
February 2025
College of Food Science and Engineering, Qingdao Agricultural University, China. Electronic address:
The study aimed to investigate the stability and anti-allergic efficacy of phycocyanin through the construction of microcapsules. Phycocyanin (PC), a blue pigment found in microalgae, has attracted significant attention due to its anti-allergic properties. However, it is susceptible to instability when exposed to light, heat, and changes in pH.
View Article and Find Full Text PDFInt J Pharm
January 2025
Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 China; Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022 China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022 China. Electronic address:
Significant efforts have been made to deliver immunosuppressants-loaded nanoparticles (NPs) to lymph nodes (LNs) to mitigate transplant rejection. However, conventional administration techniques encounter challenges in enhancing the retention of NPs in the LNs. Attributing the strong affinity of tannic acid (TA) molecules to the elastin of LN conduits, we developed a novel formulation of NPs encapsulating Tacrolimus (FK506), and subsequently modified with TA to produce TA-FNP with a final diameter of approximately 86.
View Article and Find Full Text PDFDig Dis Sci
January 2025
Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88, Olympic-ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Aims: Small bowel capsule endoscopy, which has been widely used to evaluate small bowel disease, has a risk of capsule retention (CR). The present systematic review and meta-analysis evaluated the accuracy of patency capsule (PC) and cross-sectional imaging (CSI) for predicting CR.
Methods: Databases, including MEDLINE/PubMed, EMBASE, Web of Science and the Cochrane library, were searched for articles through August 15, 2023, that investigated the diagnostic accuracy of PC or CSI for predicting CR.
J Colloid Interface Sci
January 2025
Department of Chemistry, Northeast Normal University, Changchun 130024, PR China. Electronic address:
The oral administration of drugs for cancer therapy can maintain optimal blood concentrations, is biologically safe and simple, and is preferred by many patients. However, the complex lumen environment, mucus layer, and intestinal epithelial cells are biological barriers that hinder the absorption of orally administered drugs. In this study, sea urchin-like manganese-doped copper selenide nanoparticles (Mn-CuSe NPs) were designed using an anion exchange method and coated with calcium alginate and chitosan (AC) to form Mn-CuSe@AC capsules.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!