AI Article Synopsis
- Diabetic nephropathy (DN) is a serious complication of diabetes characterized by proteinuria, which significantly impacts its progression, making protein reduction a key treatment goal.
- Traditional Chinese medicine (TCM) has been explored as a potential treatment option for managing proteinuria in DN, leading to this study's meta-analysis of its clinical effectiveness.
- The study will assess various randomized controlled trials using extensive databases and specific methodological guidelines to evaluate TCM's role in treating DN proteinuria, including its effectiveness and recurrence rates.
Article Abstract
Background: Diabetic nephropathy (DN) is one of the microvascular complications of diabetes mellitus. Proteinuria is the most important clinical feature of DN and an independent risk factor for the progression of DN. Therefore, reducing urinary protein is the primary goal of DN treatment. Traditional Chinese medicine (TCM) has long been widely used in the treatment of DN. Therefore, this paper conducted a meta-analysis of the clinical efficacy of TCM in the treatment of DN proteinuria, to comprehensively analyze the role of TCM in the treatment of DN.
Methods: We will search for PubMed, Cochrane Library, AMED, EMbase, WorldSciNet, Nature, Science online and China Journal Full-text Database, China Biomedical Literature CD-ROM Database, and related randomized controlled trials included in the China Resources Database. The time is limited from the construction of the library to September 2019. We will use the criteria provided by Cochrane 5.1.0 for quality assessment and risk assessment of the included studies, and use the Revman 5.3 and Stata13.0 software for meta-analysis of the effectiveness, recurrence rate, and symptom scores of DN proteinuria.
Trial Registration Number: PROSPERO CRD42019139707.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824702 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000017495 | DOI Listing |
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