Clostridium chauvoei is the etiological agent of blackleg, an infectious disease affecting cattle and small ruminants worldwide. This disease can manifest as classical blackleg, a condition in which skeletal muscles are affected and visceral blackleg, which affects the heart, sublingual muscles, and the diaphragm. The pathogenesis of the visceral form of the disease is poorly understood. The objective of this study is to determine and analyze complete genomic sequences of six C. chauvoei strains, five isolates from skeletal muscle and one isolate from a visceral case of blackleg in Brazil, to provide insights into the differences in pathogenic profiles of strains causing the different forms of disease. The full genomes of the six C. chauvoei strains were sequenced and comparative analyses were performed among these genomes and the C. chauvoei reference strain JF4335. The results of this study revealed that the genomes of the C. chauvoei strains analyzed are highly conserved; no particular differences were noted that could be associated with the two different clinical manifestations of the disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455654 | PMC |
| http://dx.doi.org/10.1007/s42770-019-00177-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Whole-genome sequence analysis of Clostridium chauvoei isolated from clinical case of black quarter (BQ) from India.
Arch Microbiol
May 2022
ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Karnataka, 560064, Bengaluru, India.
Black quarter (BQ) is an infectious disease affecting cattle and small ruminants worldwide caused by Gram-positive anaerobic bacterium Clostridium chauvoei. In this study, a draft genome sequence of C. chauvoei NIVEDIBQ1 strain isolated from clinical case of black quarter was analyzed.
View Article and Find Full Text PDFFirst Comparative Analysis of Genomes Provides Insights Into the Taxonomy, Species Genetic Diversity, and Virulence Related to Gas Gangrene.
Front Microbiol
December 2021
Institute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, Jena, Germany.
Article Synopsis
- The study focuses on a dangerous Gram-positive bacterium responsible for gas gangrene, which is often fatal in both humans and animals.
- Researchers sequenced and analyzed the complete genome of a specific strain alongside five others to understand genetic diversity and structures better.
- Findings revealed a stable genetic group with variations in accessory genes and a range of potential virulence factors, highlighting insights into the pathogen's relatedness and virulence mechanisms.
Genome Sequence Analysis of Strains of European Origin and Evaluation of Typing Options for Outbreak Investigations.
Front Microbiol
September 2021
Institute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, Jena, Germany.
Article Synopsis
- Black quarter is a serious bacterial disease affecting cattle and sheep, leading to high mortality rates, and a study analyzed 64 strains mainly from Europe to explore their genetic differences.
- The pangenome analysis revealed limited gene variation, with all strains possessing a CRISPR type I-B system for immunity, but homologous recombination was less frequent compared to similar pathogens, suggesting a stable genome.
- The findings indicate that outbreak strains are often related to previous local strains, highlighting the importance of understanding genetic changes at the farm level to tackle the disease effectively.
Computational Design of a Multi-epitope Vaccine Against : An Immunoinformatics Approach.
Int J Pept Res Ther
September 2021
Genetic Engineering and Biotechnology Institute, TUBITAK, 41470 Gebze, Kocaeli Turkey.
Article Synopsis
- Blackleg is an infectious disease in animals caused by localized muscle necrosis, and this study aims to develop a multi-epitope vaccine to combat it.
- Researchers used bioinformatics to analyze proteins from various bacterial strains and identified seven potential antigenic proteins as vaccine candidates.
- The final vaccine construct was validated for stability and binding effectiveness with bovine Toll-like receptor 4, indicating its potential use in clostridial vaccines to control blackleg disease.
Genomic comparison of Clostridium chauvoei isolates from classical and visceral clinical manifestation.
Braz J Microbiol
September 2020
Laboratório de Bacteriologia, Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Clostridium chauvoei is the etiological agent of blackleg, an infectious disease affecting cattle and small ruminants worldwide. This disease can manifest as classical blackleg, a condition in which skeletal muscles are affected and visceral blackleg, which affects the heart, sublingual muscles, and the diaphragm. The pathogenesis of the visceral form of the disease is poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!