Objective: is known for its antioxidant properties. In this experimental study, we aimed to investigate the efficacy of in ischemia-reperfusion (I/R) liver injury in rats.
Methods: Male Wistar Albino rats were divided into three groups, where the sham group (n=7) underwent no medication or surgical procedures, the I/R group (n=7) was the control group that received 45 minutes of applied abdominal aorta ischemia and rats were sacrificed 24 hours after reperfusion, and the I/R+ group (n=7) was the treatment group that was given (30 mg/kg) every day followed by gastric lavage for a month before applying ischemia and performing sacrifice as in the previous group. Before sacrifice, all the liver tissues were removed. Tissues were examined for histopathological investigation, iNOS immunoreactivity and tissue biochemistry, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities.
Results: The SOD, CAT, and GSH-Px levels of the I/R+ group were not significantly different from the sham group (p>0.05) but were significantly higher when compared to the I/R group. MDA levels of liver tissues were significantly lower (p<0.05) in the I/R+ group as compared to the I/R group. Disrupted hepatic cords, sinusoidal dilatation, hemorrhage, cytoplasmic vacuolization of hepatocytes, and intensive iNOS immunoreactivity were detected in the I/R group. Decreased histopathological change score and iNOS immunoreactivity score were noticed in the I/R+ group as compared to the I/R group.
Conclusion: It was found that showed a hepatoprotective effect against I/R injury. Further research is required to determine the effective dose, administration method, and effects of for liver transplantation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790936 | PMC |
| http://dx.doi.org/10.14744/nci.2018.82957 | DOI Listing |
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