Purpose: To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics.
Methods: This study used prospective, noncomparative case series, including 21 eyes of 21 healthy individuals. The 6 × 6-mm macular area was imaged repeatedly to obtain two cube image sets. Images from structural OCT (OCT-S) and OCT angiography (OCT-A) were exported. After vessel-like structures segmentation from the inverted black and white OCT-S images and the OCT-A images, both types of images were reconstructed in a 3D model. The volumes of the outer choroid and the choroidal vessels were measured after thresholding. The similarities of the segmented choroidal vessels (between OCT-S and OCT-A) and between repeatedly acquired images were measured.
Results: Mean vessel volume was 2.227 mm (29% of the outer choroidal volume) in OCT-S and 0.848 (11%) in OCT-A when measured after removal of the choriocapillaris equivalent volume. Three percent of the vessel volume in OCT-S and 8.4% of that in OCT-A overlapped. The Dice similarity coefficient of vessel volumes in repeated images from the same individual was 0.863 in OCT-S and 0.485 in OCT-A. The ratio of vessel volume to the outer choroidal volume was invariant in OCT-S but increased in OCT-A in the eyes with long axial length.
Conclusions: Hybrid 3D vascular models of the choroidal vasculature were reconstructed from OCT-S and OCT-A. The new models should prove useful for volumetric analysis of the choroid.
Translational Relevance: Hybrid 3D models of the choroidal vasculature enable volumetric analysis and facilitate morphologic evaluation.
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| http://dx.doi.org/10.1167/tvst.8.5.31 | DOI Listing |
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