AI Article Synopsis
- Systemic sclerosis (SSc) is a rare connective tissue disorder that leads to fibrosis affecting both the skin and internal organs.
- A key feature of SSc is the presence of antibodies, particularly antinuclear antibodies (ANA), which are positive in 97% of cases.
- The reported case is unusual because the patient tested negative for all common antibodies associated with SSc, including ANA, Anti-topoisomerase I, Anti-centromere, and Anti-RNA polymerase III.
Article Abstract
Systemic sclerosis (SSc) is an uncommon connective tissue disorder characterized by multisystem involvement with fibrosis of skin and internal organs. Antibody formation is one of the hallmarks of SSc. Antinuclear antibodies (ANA) are positive in 97% of patients with SSc. We report a rare case where the patient was negative for ANA, Anti-topoisomerase I, Anti-centromere and Anti-RNA polymerase III antibodies.
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| http://dx.doi.org/10.4081/reumatismo.2019.1170 | DOI Listing |
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