Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, VER 91193, Mexico.
Published: January 2020
AI Article Synopsis
Article Abstract
Evidence suggests an important role of Pavlovian learning in sexual partner selection. Female rats that experience paced copulation with a male scented with a neutral odor selectively solicit and receive ejaculations from the scented male relative to an unscented male. Exposure to the conditioned odor alone induces Fos protein in regions of the brain associated with sexual excitation. Here we tested whether female rats can be conditioned to show a sexual preference for an unscented male rat of the same strain. Female Long-Evans rats were given 10 copulatory trials with either a one-hole pacing divider or a four-hole pacing divider in a unilevel chamber with the same conspecific male (n = 16). Females were then given an open-field partner preference test with the paired male versus a novel male. After two reconditioning trials females were exposed to the partner or a novel male to induce Fos expression. Females that paced with the one-hole divider received the first ejaculation and more ejaculations overall from the paired compared to novel male. Fos immunoreactivity within oxytocin neurons in the PVN, mPOA, and VMH was increased in females with a preference that were exposed to the paired male. These data indicate that female rats can form selective sexual preferences for an individual conspecific and that their formation depends on the type of pacing during conditioning. These findings further suggest the involvement of oxytocin in the display of conditioned preferences. Thus, early copulatory experience appears to determine the mating strategy used by female rats.
Unlabelled: Valproic acid (VPA) demonstrates teratogenic effects during pregnancy. Prenatal exposure to VPA may result in autism spectrum disorder (ASD) -like phenotypes. Apigenin, a natural flavonoid, has been shown to have neuroprotective impacts due to its antioxidant properties.
Platypuses are a unique freshwater mammal native to eastern Australia. They are semi-aquatic, predominantly nocturnal, and nest in burrows dug into the banks of waterbodies. Quantifying nesting burrow characteristics is challenging due to the species' cryptic nature.
The present study evaluated the antioxidant and anti-inflammatory properties of (CA) fruit extract against bisphenol A (BPA)-induced ovarian injury in female Wistar rats. The antioxidant activity was estimated by the total antioxidant capacity (TAC) and superoxide radical (NBT) content. For the in vivo analyses, 24 animals were divided into the following 4 groups: the control group; the BPA group (50 mg/kg BW BPA for 30 days); the BPA + CA group (50 mg/kg BW BPA and 50 mg/kg BW CA); and the CA group (50 mg/kg BW CA).
Background And Objectives: Maternal western-style diets that are high in glucose and fat have well-known cardiovascular effects on offspring, yet the combined influence of such diets during pregnancy is relatively less comprehended. This study investigates the impact of maternal high glucose and fat diet (HGF) on vascular constriction in offspring and the underlying mechanisms.
Methods And Results: Pregnant Sprague-Dawley rats were provided with either HGF or control diets.
Sodium dehydroacetate (DHA-Na), a widely used preservative, can induce sex-differentiated coagulation disorders primarily resulting from its metabolism. However, the underlying mechanisms remain poorly understood. Here, we identified several Cytochrome P450 (CYP450) sub-enzymes involved in sex differences related to DHA-Na metabolism, along with two related DHA-Na metabolites.
