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The Impact of Addiction Consultation and Medication for Opioid or Alcohol Use Disorder on Hospital Readmission.
J Gen Intern Med
January 2025
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Background: Patients with substance use disorder (SUD) are frequently hospitalized and readmitted. Hospitalization is an opportunity for treatment initiation, including medications for alcohol (MAUD) and opioid use disorder (MOUD). Addiction consult teams are one model for increasing hospital-based SUD treatment.
View Article and Find Full Text PDFMicrovascular dysfunction, mitochondrial reprogramming, and inflammasome activation as critical regulators of ischemic stroke severity induced by chronic exposure to prescription opioids.
J Neurosci
January 2025
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular Biology, Miami, FL 33136.
The opioid epidemic endangers not only public health but also social and economic welfare. Growing clinical evidence indicates that chronic use of prescription opioids may contribute to an elevated risk of ischemic stroke and negatively impact post-stroke recovery. In addition, NLRP3 inflammasome activation has been related to several cerebrovascular diseases, including ischemic stroke.
View Article and Find Full Text PDFEffect of providing at-home opioid disposal kits at discharge after an orthopaedic surgery.
BMJ Open Qual
January 2025
Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Prescription opioids after surgery may pose a risk if left unused. However, prescribers rely on their best judgement in determining how much their patients need, often resulting in over-prescription of these medications. Opioid disposal is a strategy to reduce the risk of persistent use or misuse of opioids.
View Article and Find Full Text PDFBariatric surgery targeting opioid prescribing: a national model for effectively reducing opioid use after bariatric surgery.
Surg Obes Relat Dis
December 2024
Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Background: Prescription opioids are responsible for a significant proportion of opioid-related deaths in the United States. Approximately 6% of opioid-naïve patients who receive opioid prescriptions after surgery become chronic opioid users. However, chronic opioid use after bariatric surgery may be twice as common.
View Article and Find Full Text PDFEarly Onset Active Inflammatory Bowel Disease Is Associated With Psychiatric Comorbidities: A Multi-Network Propensity-Matched Cohort Study.
Crohns Colitis 360
January 2025
Digestive Health Institute, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Background: Psychiatric disease burden in patients with Inflammatory bowel disease (IBD) has risen substantially over the past few decades. However, there is limited data on the relationship between IBD disease activity and the incidence of psychiatric comorbidities. We sought to conduct a population-based study to investigate the impact of early onset disease activity in newly diagnosed IBD patients on psychiatric disease diagnoses and medication usage.
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