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Effect of L. Polysaccharide on Lewis Lung Cancer Mice by Inflammatory Regulation and Gut Microbiota Modulation.
Foods
November 2024
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Lung cancer is the leading cause of cancer-related fatalities globally, related to inflammatory and gut microbiota imbalance. L. polysaccharide (BP) is a functional compound, which is utilized by the gut microbiota to regulate immunity and metabolism.
View Article and Find Full Text PDFMultiaction Pt(IV) Complexes: Cytotoxicity in Ovarian Cancer Cell Lines and Mechanistic Studies.
Inorg Chem
August 2024
School of Biological and Chemical Sciences, University of Galway, Galway H91 TK33, Ireland.
Ovarian cancer has the worst case-to-fatality ratio of all gynecologic malignancies. The main reasons for the high mortality rate are relapse and the development of chemoresistance. In this paper, the cytotoxic activity of two new multiaction platinum(IV) derivatives of cisplatin and oxaliplatin in a panel of ovarian cancer cells is reported.
View Article and Find Full Text PDFClinical toxicology of acute glyphosate self-poisoning: impact of plasma concentrations of glyphosate, its metabolite and polyethoxylated tallow amine surfactants on the toxicity.
Clin Toxicol (Phila)
August 2024
University of South Australia Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
Introduction: Common major co-formulants in glyphosate-based herbicides, polyethoxylated tallow amine surfactants, are suspected of being more toxic than glyphosate, contributing to the toxicity in humans. However, limited information exists on using polyethoxylated tallow amine concentrations to predict clinical outcomes. We investigated if plasma concentrations of glyphosate, its metabolite and polyethoxylated tallow amines can predict acute kidney injury and case fatality in glyphosate poisoning.
View Article and Find Full Text PDFMUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis.
Gut Microbes
June 2024
College of Food Science and Engineering, Northwest A&F University, Yang ling, Shaanxi, China.
Alcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities. Dysbiosis of the gut microbiome is associated with the development of ALD, with the gut microbial metabolite urolithin A (UA) exhibiting a potential for alleviating liver symptoms. However, the protective efficacy of UA against ALD and its underlying mechanism mediated by microbiota remain elusive.
View Article and Find Full Text PDFLung cancer ranks among the primary contributors to cancer-related fatalities on a global scale. Multiple research investigations have demonstrated that there exists a dysbiosis within the intestinal bacteria and short-chain fatty acids (SCFAs) is linked with immune responses in lung cancer. Qingfei mixture (QFM) has been widely used in treating lung cancer, yet the active ingredients and roles of the QFM on immune responses by targeting gut microbiota remain to be elucidated.
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