In a preliminary screening, the methanol extract of leaves was found to inhibit the swarming motility of . Bioassay-guided fractionation by silica gel column chromatography led to the identification of cinnamtannin B1 () as one of the active components of the extract. It inhibited the swarming motility (at 12.5 μg/mL) and biofilm formation (at 25 μg/mL) of. Comparative gene expression analysis revealed downregulation of A and C genes upon treatment with the tannin. The tannin may be affecting rhamnolipid and flagellin production. Thus, cinnamtannin B1 is an active component of responsible for inhibiting the swarming motility of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796927 | PMC |
| http://dx.doi.org/10.1021/acsomega.9b02471 | DOI Listing |
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