AI Article Synopsis
- - The study explored the impact of vitamin D levels on lipid profiles among 315 nonsmoking premenopausal women, categorizing participants into four groups based on their vitamin D status.
- - Results indicated that higher vitamin D levels (group 4) were associated with increased HDL cholesterol, while lower vitamin D levels (group 1) correlated with higher triglycerides and non-HDL cholesterol.
- - Despite initial correlations between vitamin D and lipid levels, after adjusting for factors like age and BMI, the study found no significant relationship between vitamin D and total or specific lipid levels, suggesting that obesity may influence this association.
Article Abstract
Unlabelled: High lipid levels play important roles in the pathogenesis of atherosclerosis and some authors suggest vitamin D deficiency as a risk factor for atherosclerosis. The aim of this study was to evaluate the effect of vitamin D status on lipid profile in premenopausal women.
Patients And Methods: A total of 315 nonsmoking premenopausal female volunteers without diabetes mellitus were included in the study. Patients were divided into four subgroups. The groups were as follows: patients with less than or equal to 12 ng/ml (group 1, =126) vitamin D levels, between 20 and 12 ng/ml (group 2, =48), between 30 and 20 ng/ml (group 3, =21), and at least 30 ng/ml (group 4, =120) vitamin D levels. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and non-HDL-C levels of the four groups were compared.
Results: HDL-C levels of group 4 were the highest (=0.03), and TG and non-HDL-C levels of group 1 were the highest (=0.04, 0.016, respectively) in all groups. There was no significant difference between serum parathormone, calcium, and phosphorus levels of the four groups (=0.778, 0.121, 0.184, respectively). In unadjusted analysis, 25-hydroxy vitamin D levels were found to be correlated negatively with BMI (=0.0005), LDL-C (=0.01), and non-HDL-C (=0.003) and correlated positively with HDL-C levels (=0.006). After adjustments for age, sex, BMI, and log parathormone levels were made, no correlation was found between 25-hydroxy vitamin D and lipid (TC, LDL-C, HDL-C, and TG) levels (=0.91, 0.06, 0.95, 0.79, respectively).
Conclusion: There may be an association between vitamin D insufficiency and dyslipidemia. However, this association may depend on obesity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768514 | PMC |
| http://dx.doi.org/10.1097/XCE.0000000000000124 | DOI Listing |
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