Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S2213-2600(19)30348-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Group 3 Innate Lymphoid Cells: A Potential Therapeutic Target for Steroid Resistant Asthma.
Clin Rev Allergy Immunol
December 2024
Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 3B.71, Baltimore, MD, 21224, USA.
Asthma is a chronic airway inflammatory disease that affects millions globally. Although glucocorticoids are a mainstay of asthma treatment, a subset of patients show resistance to these therapies, resulting in poor disease control and increased morbidity. The complex mechanisms underlying steroid-resistant asthma (SRA) involve Th1 and Th17 lymphocyte activity, neutrophil recruitment, and NLRP3 inflammasome activation.
View Article and Find Full Text PDF[Recent progress in the treatment of non-T2 asthma].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
December 2024
Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guilin Medical College, Guilin 541000, China *Corresponding author, E-mail:
Non-T2 asthma, also known as non-eosinophilic asthma or low T2 asthma, does not have markers of type 2 inflammation and is often associated with hormone insensitivity and severe asthma. This article reviews the progress in drug therapy for non-T2 asthma.
View Article and Find Full Text PDFOsteopontin as a Novel Biomarker in Distinguishing Chronic Rhinosinusitis with Nasal Polyp Endotypes and Predicting Disease Severity.
Int Arch Allergy Immunol
November 2024
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Introduction: The objective of this study was to ascertain the predictive value of osteopontin (OPN), a cytokine with pro-inflammatory properties implicated in inflammatory and allergic conditions, in nasal secretions for the identification of chronic rhinosinusitis with nasal polyp (CRSwNP) endotypes and the assessment of disease severity.
Methods: A cohort comprising 81 individuals diagnosed with CRSwNP was enrolled, which included 37 subjects with the non-eosinophilic CRSwNP and 44 subjects with the eosinophilic CRSwNP (eCRSwNP), alongside 32 healthy controls (HCs). Nasal secretions and tissue samples were collected from all participants.
Evaluating Severe Therapy-Resistant Asthma in Children: Diagnostic and Therapeutic Strategies.
Medicina (Kaunas)
November 2024
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
Article Synopsis
- Asthma is the most prevalent non-communicable respiratory disease globally, leading to significant health issues and costs, especially for the 10% of patients with severe, uncontrolled forms.
- Research highlights that many children and adolescents with asthma can be effectively managed with standard treatments, emphasizing the importance of correct basic management and multi-disciplinary assessments.
- For patients with true therapy-resistant asthma, new monoclonal antibody treatments targeting type 2 inflammation are available, but there remains a lack of options for non-eosinophilic asthma.
Correlation between Lund-Mackay computed tomography score and subjective symptoms in Chinese patients with nasal polyps.
Acta Otolaryngol
October 2024
ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Background: The association between objective imaging findings and subjective symptoms remains undefined.
Aims: To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation.
Methods: Patients with CRSwNP undergoing endoscopic sinus surgery were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!