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Placental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy.
Early Hum Dev
December 2024
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:
Article Synopsis
- This study investigates the link between placental lesions and neonatal hypoxic-ischemic encephalopathy (HIE), focusing on mild versus moderate to severe cases of HIE.
- Researchers analyzed data from 394 neonates diagnosed with HIE, finding that inflammatory responses in placentas were more common in those with moderate to severe HIE compared to mild cases.
- The results indicate that increased severity of placental inflammatory responses correlates with higher severity levels of HIE, emphasizing the potential impact of placental health on neonatal outcomes.
Machine learning models of cerebral oxygenation (rcSO) for brain injury detection in neonates with hypoxic-ischaemic encephalopathy.
J Physiol
November 2024
INFANT Research Centre, University College Cork, Cork, Ireland.
The present study was designed to test the potential utility of regional cerebral oxygen saturation (rcSO) in detecting term infants with brain injury. The study also examined whether quantitative rcSO features are associated with grade of hypoxic ischaemic encephalopathy (HIE). We analysed 58 term infants with HIE (>36 weeks of gestational age) enrolled in a prospective observational study.
View Article and Find Full Text PDFCirculating MicroRNAs as a biomarker signature of perinatal asphyxia.
Pediatr Neonatol
August 2024
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:
Aim: This study aimed to explore whether microRNAs (miRNAs) could serve as biomarkers of perinatal asphyxia and whether they were correlated with severity of brain magnetic resonance imaging.
Methods: We prospectively enrolled 26 full-term newborns, including 10 with perinatal asphyxia and 16 healthy controls. Plasma samples were collected at 0-6 h and 7 days of age.
Prognostic value of quantitative EEG in early hours of life for neonatal encephalopathy and neurodevelopmental outcomes.
Pediatr Res
August 2024
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
- A study was conducted to evaluate a new measure called the brain state of newborn (BSN) to identify hypoxic ischemic encephalopathy (HIE) in newborns shortly after birth and predict their neurodevelopmental health at 2 years old.
- The researchers used a modified Sarnat exam and EEG readings to calculate BSN and Total Sanart Score (TSS) in newborns, allowing them to differentiate between those with and without significant developmental issues.
- The findings show that BSN is an effective real-time indicator for monitoring encephalopathy severity and correlates with future neurodevelopmental outcomes, indicating its potential use in clinical settings for early interventions.
Whole-body hypothermia in mild neonatal encephalopathy: protocol for a multicentre phase III randomised controlled trial.
BMC Pediatr
July 2024
Centre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, Du Cane Road, London, W12 0HS, England.
Article Synopsis
- The COMET trial aims to determine if whole-body hypothermia can improve cognitive development in neonates with mild hypoxic ischemic encephalopathy, a condition linked to learning difficulties.
- It is a phase III multicenter randomized controlled trial involving 426 neonates, comparing hypothermia treatment (33.5°C) to normothermia (37.0°C) within the first six hours of birth.
- The primary goal is to evaluate cognitive outcomes at two years using the Bayley scales, while also ensuring the trial's safety and assessing healthcare resource utilization.
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