A methanol extract of the stem bark of the Malayan provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, -) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, ). Analysis of the spectroscopic data (NMR and MS) of these compounds led to the proposed structures of these alkaloids. The macroline-sarpagine alkaloids (-) showed in vitro growth inhibitory activity against a panel of human cancer cell lines, inclusive of KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, HCT 116, and A549 cells (IC values: 0.02-9.0 μM).
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| http://dx.doi.org/10.1021/acs.jnatprod.9b00712 | DOI Listing |
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