AI Article Synopsis
- Researchers studied the expression of PE_PGRS51, a protein involved in tuberculosis, amidst challenges due to similarities within its family proteins.
- They used blood samples from TB patients to analyze how antibodies reacted to different parts of PE_PGRS51, revealing that specific antibodies appear at various stages of the disease.
- The findings suggest that antibodies targeting unique areas of PE_PGRS51 could indicate the presence and progression of tuberculosis.
Article Abstract
Background: Intrafamily homology has impeded correlation of expression of individual PE_PGRS proteins with stage of tuberculosis (TB). We investigated the in vivo expression of PE_PGRS51, which has 3 unique regions.
Methods: Sera from patients across the spectrum of TB were used to screen peptide arrays spanning PE_PGRS51.
Results: Antibodies against a subset of conserved "core epitopes" within PE/PGRS domains are elicited during early TB. The epitope repertoire expands to adjacent regions with disease progression. Antiunique region antibodies appear only during cavitary TB.
Conclusions: Elicitation of antiunique region antibodies can serve as markers for in vivo expression of PE_PGRS proteins.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137892 | PMC |
| http://dx.doi.org/10.1093/infdis/jiz546 | DOI Listing |
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