Catalytic Asymmetric Aza-Friedel-Crafts-Type Reaction of Indoles with Isatin-Derived -Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst.

Takayoshi Arai Kensuke Araseki Junki Kakino

Org Lett

Soft Molecular Activation Research Center (SMARC), Chiba Iodine Research Innovation Center (CIRIC), and Department of Chemistry, Graduate School of Science , Chiba University, 1-33 Yayoi, Inage , Chiba 263-8522 , Japan.

Published: November 2019

A chiral bis(imidazolidine)-containing NCN-pincer palladium complex (Bu-PhBidine-Pd-OTf) was an efficient catalyst for the aza-Friedel-Crafts-type reaction of 1H-indoles with isatin-derived Cbz-ketimines to give chiral 3-aminobisindole compounds having differently oxidized indole units with high enantioselectivities.

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http://dx.doi.org/10.1021/acs.orglett.9b03148	DOI Listing

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