Preoperative carbohydrate loading is a contemporary element of the enhanced recovery after surgery (ERAS) paradigm. In addition to intraoperative surgical and anesthetic modifications and postoperative care practices, preoperative optimization is essential to good postsurgical outcomes. What was long held as dogma, a period of prolonged fasting prior to the administration of anesthesia, was later re-examined and challenged. Along with the proposed physiologic effects of decreasing the surgical stress response and insulin resistance, preoperative carbohydrate loading was also demonstrated to improve patient satisfaction and well-being, without an increase in perioperative complications. The benefits are most strongly observed in abdominal and cardiac surgery patients, but there has also been data which support its use in other specialties and surgeries. Barriers to the adoption of perioperative carbohydrate loading are few, but importantly include overcoming the inertia to modify older and more restrictive fasting guidelines and achieving the multidisciplinary consensus necessary to implement such changes. Despite these challenges, and with an existing body of evidence supporting its benefits, preoperative carbohydrate loading presents a significant contribution to the ERAS programs.
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http://dx.doi.org/10.1002/ncp.10427 | DOI Listing |
Molecules
December 2024
Laboratoire de Réactivité et Chimie des Solides (LRCS), UMR CNRS 7314, Université de Picardie Jules Verne, Hub de L'énergie, 15 rue Baudelocque, FR-80000 Amiens, France.
Confronting escalating challenges in energy security and environmental sustainability has intensified interest in renewable sources for fuels and chemicals. Among the most promising alternatives, sugars derived from biomass are emerging as a cornerstone in advancing an environmentally sustainable economy. Within this framework, the development of sunlight-driven carbohydrate oxidation is of significant interest, as it enables the production of a broad spectrum of high-value, bio-sourced chemicals through eco-friendly processes.
View Article and Find Full Text PDFAnn Surg
January 2025
Division of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; Boston, MA, USA.
Objective: To explore the association of socioeconomic status (SES) and race/ethnicity with perioperative metrics within the Enhanced Recovery After Surgery (ERAS) framework to identify gaps for equity-informed improvements.
Summary Background Data: Although ERAS pathways improve perioperative outcomes through standardized care, disparities in protocol adherence and postoperative outcomes persist, particularly for vulnerable populations.
Methods: We conducted a retrospective cohort study using a single-institution database of elective colorectal surgeries (2018-2021).
Carbohydr Polym
March 2025
National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, Shandong 266237, China; Suzhou Research Institute of Shandong University, Suzhou, Jiangsu 215123, China. Electronic address:
Camptothecin (CPT) exhibits potent anticancer activity, but its clinical application is limited by poor solubility and severe side effects. Hyaluronic acid (HA) is gaining attention in drug delivery systems due to its excellent biocompatibility and tumor-targeting properties. In this study, we conjugated CPT to the reducing end of ultra-low molecular weight HA to create a series of HA-decorated CPT conjugates.
View Article and Find Full Text PDFTalanta
January 2025
College of Chemistry and Materials, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, 330022, China.
Levels of CA125 are strongly associated with cervical, pancreatic, bowel and breast cancer. However, the common CA125 detection method has the disadvantages of poor repeatability, high cost, easy to be disturbed and poor stability. In this work, a COF based electrochemical immunosensor was developed for the rapid, sensitive and stable detection of CA125.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Food and Nutrition, Hannam University, Daejeon 34054, Republic of Korea.
Citrus fruits are widely distributed in East Asia, and tea made from citrus peels has demonstrated health benefits, such as a reduction in fever, inflammation, and high blood pressure. However, citrus leaves have not been evaluated extensively for their possible health benefits. In this study, the α-glucosidase-inhibitory activity of Jeju citrus hot-water (CW) and ethyl alcohol (CE) extracts, along with hesperidin (HP) (a bioactive compound in citrus leaf extracts), was investigated, and furthermore, their effect on postprandial blood glucose reduction in an animal model was determined.
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