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Environmental risk assessment methodology for urban tropical lagoons based on feasible lines of evidence under limited resources conditions: Jacarepaguá Lagoon/Brazil.
Ecotoxicology
January 2025
Department Sanitary and Environmental Engineering, Rio de Janeiro State University-UERJ, Rio de Janeiro, CEP, Brazil.
Determining environmental risk levels posed to different urban lagoon can provide an important overview regarding the relative severity of the environmental degradation of these ecosystems, increasing the risks visibility, which can be used as an important decision-making tool to prioritize investments. Jacarepaguá Lagoon (JPAL) is part of a coastal lagoon system comprising four interconnected lagoons in Rio de Janeiro city, Southeastern Brazil. Real estate speculation and insufficient sanitation infrastructure resulted in untreated sewage discharge into this ecologically sensitive lagoon system.
View Article and Find Full Text PDFProgressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium.
J Clin Invest
January 2025
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Article Synopsis
- IPF development involves a two-hit process: an initial vulnerability of the lung's epithelial cells followed by a second injury that triggers fibrotic changes.
- Genetic factors play a crucial role in the first hit, while ongoing damage disrupts normal cell function and activates fibroblasts, leading to lung fibrosis.
- Understanding IPF in terms of its stages may lead to new treatments that target these underlying causes, aiming for a shift from palliative care to potential cures for patients.
An assessment of cryptocurrencies as a global commercial determinant of health.
Health Promot Int
December 2024
Nottingham Centre for Public Health and Epidemiology, School of Medicine, University of Nottingham, Hucknall Rd, Nottingham NG5 1PB, UK.
Through the commercial determinants of health framework, gambling has been identified as a powerful threat to health. This research critically examines cryptocurrency, which is promoted and sold as a highly gamblified product. Using the commercial determinants of health framework, the multifaceted ways in which cryptocurrency firm operations may impact health outcomes are highlighted.
View Article and Find Full Text PDFDeep recurrent Q-network algorithm for carbon emission allowance trading strategy.
J Environ Manage
December 2024
Accounting School, Hunan University of Finance and Economics, Changsha, 410083, China. Electronic address:
Article Synopsis
- - The carbon trading market, crucial in combating global warming, requires efficient methods for companies and individuals to find investment opportunities and make intelligent trading decisions, which is addressed by a new deep reinforcement learning strategy called Deep Recurrent Q-Network (DRQN).
- - The research demonstrates that the DRQN model yields optimal trading strategies, showing impressive annualized returns of 15.43% in the Guangdong market and 34.75% in Hubei, surpassing other trading strategies.
- - An analysis of the impacts of discount factors and trading costs reveals that an optimal discount factor of 0.4 can clarify expectations for traders, while government regulation of trading costs can help maintain fair practices in carbon trading and reduce speculation. *
ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis.
J Invest Dermatol
October 2024
Université Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, Orsay, France.
CXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound healing, with emphasis on fibrotic and regenerative responses; and explore their relevance in skin responses to commensals and pathogens. Given the lack of knowledge surrounding ACKR3, the atypical receptor of CXCL12, we speculate whether and how it might be involved in the processes mentioned earlier.
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