AI Article Synopsis
- The study analyzes the activities of alkaline phosphatase (AP) and lactate dehydrogenase (LDG) in rat blood serum and osteogenic sarcomas after exposure to plutonium-239 and gamma radiation.
- It finds a correlation between alkaline phosphatase levels and the histological structure of the sarcomas, as well as patterns in metastases.
- Changes in the isoenzymic spectrum of lactate dehydrogenase in both neoplastic bone tissues and blood serum were noted, particularly an increase in LDG3 and LDG4 fractions and a decrease in LDG5.
Article Abstract
Alkaline phosphatase (AP) and lactate dehydrogenase (LDG) activities are stained in rat blood serum and osteogenic sarcomas of different histostructure, which developed following a combined exposure of 239Pu (92.5 kBq/kg of body mass) and gamma-irradiation (103.2 mC/kg), as well as following separate exposures to these factors at the same doses. Alkaline phosphatase activities in blood serum and neoplastic bone tissues were found to correlate with the histostructure of osteogenic sarcomas, the distribution and the localization of metastases. Shifts in an isoenzymic spectrum of lactate dehydrogenase in neoplastic bone tissues and blood serum are observed, with a tendency to an increase in the LDG3 and LDG4 and to a decrease in the LDG5 fractions.
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