The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956161 | PMC |
| http://dx.doi.org/10.3390/biology8040079 | DOI Listing |
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