AI Article Synopsis
- The study explores the potential of using microbubble ultrasound contrast agent, SonoVue, as a less invasive method for estimating cardiac and aortic pressures, traditionally measured with invasive catheters.
- Researchers investigated how the subharmonic response of SonoVue varies with hydrostatic pressures in a controlled environment using specific equipment.
- Findings indicate that the subharmonic amplitude of SonoVue tends to increase with pressure up to 50 mmHg, but starts to decrease at higher pressures, suggesting that changes in the microbubble's physical properties influence this relationship.
Article Abstract
The measurement of cardiac and aortic pressures enables diagnostic insight into cardiac contractility and stiffness. However, these pressures are currently assessed invasively using pressure catheters. It may be possible to estimate these pressures less invasively by applying microbubble ultrasound contrast agents as pressure sensors. The aim of this study was to investigate the subharmonic response of the microbubble ultrasound contrast agent SonoVue (Bracco Spa, Milan, Italy) at physiological pressures using a static pressure phantom. A commercially available cell culture cassette with Luer connections was used as a static pressure chamber. SonoVue was added to the phantom, and radio frequency data were recorded on the ULtrasound Advanced Open Platform (ULA-OP). The mean subharmonic amplitude over a 40% bandwidth was extracted at 0-200-mmHg hydrostatic pressures, across 1.7-7.0-MHz transmit frequencies and 3.5%-100% maximum scanner acoustic output. The Rayleigh-Plesset equation for single-bubble oscillations and additional hysteresis experiments were used to provide insight into the mechanisms underlying the subharmonic pressure response of SonoVue. The subharmonic amplitude of SonoVue increased with hydrostatic pressure up to 50 mmHg across all transmit frequencies and decreased thereafter. A decreasing microbubble surface tension may drive the initial increase in the subharmonic amplitude of SonoVue with hydrostatic pressure, while shell buckling and microbubble destruction may contribute to the subsequent decrease above 125-mmHg pressure. In conclusion, a practical operating regime that may be applied to estimate cardiac and aortic blood pressures from the subharmonic signal of SonoVue has been identified.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053253 | PMC |
| http://dx.doi.org/10.1109/TUFFC.2019.2948759 | DOI Listing |
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