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Clinical Study of Intradermal Injection of Non-Crosslinked Sodium Hyaluronate Combined With Human Epidermal Growth Factor in the Treatment of Skin Barrier Injury in Plateau Area.
J Cosmet Dermatol
December 2024
Department of Plastic Surgery, Affiliated Calmette Hospital of Kunming Medical University, Kunming, China.
Background: The Yunnan-Guizhou Plateau's high-altitude setting is characterized by intense solar ultraviolet radiation, a significant environmental stressor that frequently leads to skin barrier damage. This damage presents clinically as erythema, itching, and desquamation, underscoring the need for effective reparative interventions.
Aims: The objective of this study was to assess the therapeutic efficacy of a novel treatment protocol that integrates non-crosslinked hyaluronic acid (HA) injection with microneedle application of human epidermal growth factor (hEGF) for the restoration of skin barrier function in regions of high altitude.
Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma.
Braz Oral Res
December 2024
Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery, Pathology and Clinical Dentistry, Belo Horizonte, MG, Brazil.
There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC.
View Article and Find Full Text PDFVascular Characteristics of Treatment-resistant and -responsive Actinic Keratosis Identified with Dynamic Optical Coherence Tomography.
Acta Derm Venereol
November 2024
Department of Dermatology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
Treatment-resistant actinic keratosis (AK) is of concern in clinical practice, often requiring retreatment. Microvascular assessments might help differentiate treatment-resistant from treatment-responsive AKs, enabling targeted treatment. Using dynamic optical coherence tomography, AK vascularization was investigated following daylight photodynamic therapy, comparing treatment-resistant with cleared AKs.
View Article and Find Full Text PDFDynamic optical coherence tomography unveils subclinical, vascular differences across actinic keratosis grades I-III.
Exp Dermatol
August 2024
Department of Dermatology, Copenhagen University Hospital, Copenhagen, Denmark.
Article Synopsis
- * The study involved 47 patients, revealing that D-OCT identified distinct vascular differences between AK grades and photodamaged skin, especially at a depth of 300μm, and showed significant differences in vessel arrangement and patterns across the various grades of AK.
- * The combined use of D-OCT and dermatoscopy proved effective in differentiating between AK grades, with results indicating increased vascularization and vessel disorganization in higher-grade AK lesions.
Enhanced skin regeneration and therapeutic delivery using novel diamond-augmented zinc oxide.
J Cosmet Dermatol
December 2024
Gold Skin Care Center, Nashville, Tennessee, USA.
Background: Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond-Augmented Zinc Oxide (ND-ZnO) technology combines zinc oxide with diamond particles in a unique core-shell structure, offering a multifaceted approach to overall skin health.
Aims: This study evaluates the efficacy of ND-ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.
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