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Late-term moderate prenatal alcohol exposure impairs tactile, but not spatial, discrimination in a T-maze continuous performance task in juvenile rats.
Behav Brain Res
October 2024
Department of Psychology, University of Kentucky, United States.
Existing maze apparatuses used in rodents often exclusively assess spatial discriminability as a means to evaluate learning impairments. Spatial learning in such paradigms is reportedly spared by moderate prenatal alcohol exposure in rats, suggesting that spatial reinforcement alone is insufficient to delineate executive dysfunction, which consistently manifests in humans prenatally-exposed to alcohol. To address this, we designed a single-session continuous performance task in the T-maze apparatus that requires rats to discriminate within and between simultaneously-presented spatial (left or right) and tactile (sandpaper or smooth) stimuli for food reinforcement across four sequential discrimination stages: simple discrimination, intradimensional reversal 1, extradimensional shift, and intradimensional reversal 2.
View Article and Find Full Text PDFThe Effect of Physical Rehabilitation on Oro-Motor Stimulation, Manual Airway Clearance, Positioning, and Tactile Stimulation (PROMPT) on Neonates With Respiratory Distress Syndrome.
Cureus
July 2024
Department of Osteopathy, Dr Hullumani's Polyclinic and Rehabilitation, Bangalore, IND.
Neonatal respiratory distress syndrome (NRDS) is a significant cause of morbidity and mortality in preterm infants due to insufficient surfactant production in the lungs. This case report explores the effect of physical rehabilitation on oro-motor stimulation, manual airway clearance, positioning, and tactile stimulation (PROMPT) approach on a preterm neonate with NRDS. The report details the pre-natal, natal, and post-natal history of the patient, including maternal health, pregnancy complications, delivery specifics, initial clinical presentation, and subsequent management.
View Article and Find Full Text PDFR-Baclofen Treatment Corrects Autistic-like Behavioral Deficits in the RjIbm(m):FH Fawn-Hooded Rat Strain.
Pharmaceuticals (Basel)
July 2024
Pharmacology and Drug Safety Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103 Budapest, Hungary.
The Fawn-hooded rat has long been used as a model for various peripheral and central disorders and the data available indicate that the social behavior of this strain may be compromised. However, a thorough description of the Fawn-hooded rat is unavailable in this regard. The objective of the present study was to investigate various aspects of the Fawn-hooded rat's social behavior in depth.
View Article and Find Full Text PDFGestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice.
Transl Psychiatry
July 2024
Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City, 133002, Jilin, China.
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for autism spectrum disorder (ASD). Numerous studies have shown that impaired synaptic transmission in the cerebellar cortical circuits is one of the reasons for the social deficits and repetitive behavior seen in ASD. In this study, we investigated the effect of VPA exposure during pregnancy on tactile stimulation-evoked cerebellar mossy fiber-granule cell (MF-GC) synaptic transmission in mice anesthetized with urethane.
View Article and Find Full Text PDFAdvancement of 3D printing technology for the development of a training model in US-guided vesicoamniotic shunting for early LUTO therapy.
Acta Obstet Gynecol Scand
August 2024
Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, Germany.
Introduction: Prenatal lower urinary tract obstruction (LUTO) is a rare and challenging condition with potential severe morbidity and mortality. Prenatal shunting methods, specifically vesicoamniotic shunting (VAS) and fetal cystoscopy, aim to manage this condition. However, comprehensive education and training are hindered by the rarity of LUTO.
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