Precursor-directed biosynthesis was used to generate a series of fluorinated verticillins. The biosynthesis of these epipolythiodioxopiperazine alkaloids was monitored via the droplet liquid microjunction surface sampling probe (droplet probe), and a suite of NMR and mass spectrometry data were used for their characterization. All analogues demonstrated nanomolar IC values vs a panel of cancer cell lines. This approach yielded new compounds that would be difficult to generate via synthesis.
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| http://dx.doi.org/10.1021/acs.jnatprod.9b00711 | DOI Listing |
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