Pecan scab, caused by , is a devastating disease of pecan (), which results in economic losses on susceptible cultivars throughout the southeastern United States. To enhance our understanding of pathogenicity in , we have generated a complete telomere-to-telomere reference genome of isolate FRT5LL7-Albino. By combining Illumina MiSeq and Oxford Nanopore MinION data, we assembled a 45.2-Mb genome represented by 20 chromosomes and containing 10,820 putative genes, of which 7,619 have at least one functional annotation. The likely causative mutation of the albino phenotype was identified as a single base insertion and a resulting frameshift in the gene encoding the polyketide synthase . This genome represents the first full chromosome-level assembly of any sp.
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http://dx.doi.org/10.1094/MPMI-08-19-0236-A | DOI Listing |
Mol Ther Nucleic Acids
March 2025
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Recent advances in molecular science have significantly enlightened our mechanistic understanding of spinocerebellar ataxia type 7. To further close remaining gaps, we performed a multi-omics analysis using SCA7 mice. Entire brain tissue samples were collected from 12-week-old mice, and RNA sequencing, methylation analysis, and proteomic analysis were performed.
View Article and Find Full Text PDFFront Parasitol
April 2024
Centre for Malaria Elimination, Institute of Tropical Medicine, Mount Kenya University, Thika, Kenya.
The Circumsporozoite Protein (PfCSP) has been used in developing the RTS,S, and R21 malaria vaccines. However, genetic polymorphisms within compromise the effectiveness of the vaccine. Thus, it is essential to continuously assess the genetic diversity of , especially when deploying it across different geographical regions.
View Article and Find Full Text PDFF1000Res
January 2025
Charles Darwin University Research Institute for the Environment and Livelihoods, Casuarina, Northern Territory, 0909, Australia.
The eastern or Tasmanian bettong ( ) is one of four extant bettong species and is listed as 'Near Threatened' by the IUCN. We sequenced short read data on the 10x system to generate a reference genome 3.46Gb in size and contig N50 of 87.
View Article and Find Full Text PDFBrain Commun
December 2024
Mitochondrial Research Group, Genetics and Genomic Medicine Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
This scientific commentary refers to 'Biallelic variants lead to a neurodevelopmental phenotype with gradual neurological impairment', by Kaiyrzhanov . (https://doi.org/10.
View Article and Find Full Text PDFGenome Med
January 2025
Otology & Neurotology Group CTS495, Instituto de Investigación Biosanitario, Ibs.GRANADA, Universidad de Granada, 18071, Granada, Spain.
Background: Familial Meniere's disease (FMD) is a rare polygenic disorder of the inner ear. Mutations in the connexin gene family, which encodes gap junction proteins, can also cause hearing loss, but their role in FMD is largely unknown.
Methods: We retrieved exome sequencing data from 94 individuals in 70 Meniere's disease (MD) families.
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