()-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of and their antimalarial and cytotoxic activities.

A new farnesylindole, ()-3-(8'-hydroxyfarnesyl)-indole (), as a scalemic mixture (33% ) along with nine known compounds (-), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from . All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds , and showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound displayed the best activity with IC values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound also presented modest cytotoxicity against a KB cell line with an IC value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells.